Modification of hydrophilicity and thrombogenicity of the surface of polymer nano-nonwovens for biomedical applications

Data included in this collection are connected with the project entitled ”Modification of hydrophilicity and thrombogenicity of the surface of polymer nano-nonwovens for biomedical applications” supported by the National Science Centre, Poland (Miniatura 8 2024/08/X/ST5/00551).

The present research focuses on the evaluation of surface modification methods for polymer electrospun nonwovens in order to improve their atrombogenic properties and regulate surface hydrophilicity. Three strategies for imparting anticoagulant properties to polymer fibrous materials were investigated using a model anticoagulant compound, ethylenediaminetetraacetic dianhydride (EDTA). The first approach involved the direct incorporation of EDTA into the fibres through electrospinning of polymer solutions containing the active compound. The second strategy consisted of surface reduction using lithium borohydride (LiBH₄) to generate reactive functional groups enabling the subsequent attachment of EDTA. The third method was based on surface activation by low-temperature plasma followed by a reaction with EDTA. The use of electrospun nonwovens allows the preparation of materials with a high specific surface area, which promotes coagulation processes and thus facilitates a clearer evaluation of the effects of surface modification. Both biodegradable materials produced from aliphatic polyesters and non-degradable materials composed of poly(carbonate urethanes) were investigated. Within each group, the polymers differed in their initial hydrophilicity.