Metrics
2 Downloads
Share Dataset

Share this dataset on your favorite social media networks.

Raw data from 'CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies'

Version 1.0

Kusowska, Aleksandra, 2025, "Raw data from 'CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies'", https://doi.org/10.18150/XKOEQA, RepOD, V1

Learn about Data Citation Standards.

Description

This study aimed to investigate mechanisms of rituximab (RTX) resistance in diffuse large B-cell lymphoma (DLBCL), with a focus on the regulation of CD37 expression. For this purpose, RTX-resistant B-cell lymphoma cell lines were generated as in vitro models. The study evaluated how changes in CD37 expression influence the efficacy of CD37-targeted therapies, including monoclonal antibodies and CAR T cells, and assessed whether CD37 remains a viable therapeutic target in the context of RTX resistance.

The dataset includes:

  • Derivation of rituximab (RTX) resistance in two cell lines, SU-DHL4 and Raji, which were used for experiments in the main body and supplementary materials of the related publication. The data contain flow cytometry readouts from complement-dependent cytotoxicity assays performed during consecutive passages with rituximab and human serum, showing how resistance was established in these cell lines.
  • Flow cytometry readouts from cytotoxicity assays involving CD37 CAR-T cells, processed for Figure 5A and 5B of the related publication.
Subject
Medicine, Health and Life Sciences
Keyword

rituximab, B-cell lymphoma, immunotherapy resistance, CAR-T cells

Related Publication

Bobrowicz M, Kusowska A, Krawczyk M, Zhylko A, Forcados C, Slusarczyk A, Barankiewicz J, Domagala J, Kubacz M, Šmída M, Dostalova L, Marhelava K, Fidyt K, Pepek M, Baranowska I, Szumera-Cieckiewicz A, Inderberg EM, Wälchli S, Granica M, Graczyk-Jarzynka A, Majchrzak M, Poreba M, Gehlert CL, Peipp M, Firczuk M, Prochorec-Sobieszek M, Winiarska M. CD20 expression regulates CD37 levels in B-cell lymphoma - implications for immunotherapies. Oncoimmunology. 2024 Jun 4;13(1):2362454. doi: 10.1080/2162402X.2024.2362454. PMID: 38846084; PMCID: PMC11155707. https://doi.org/10.1080/2162402X.2024.2362454 doi: 10.1080/2162402X.2024.2362454

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

Find
1 to 2 of 2 Files
CD37 CAR-T cytotoxicity.tab
Tabular Data - Original format: MS Excel (XLSX) - 3.4 KB - Oct 13, 2025 - 1 Download
License: CC BY - Creative Commons Attribution 4.0
24 Variables, 30 Observations - UNF:6:dpHavumSB/oMQJH0xqv4JA==
Preview
Derivation of RTX resistance.tab
Tabular Data - Original format: MS Excel (XLSX) - 4.8 KB - Oct 13, 2025 - 1 Download
License: CC BY - Creative Commons Attribution 4.0
16 Variables, 53 Observations - UNF:6:ctexfgtZUcfSwdkPeJx2KQ==
Preview
Select File(s)

Please select a file or files to be deleted.

Delete Files

The file(s) will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Select File(s)

Please select a file or files to be edited.

Select File(s)

Please select a file or files to be edited.

Select File(s)

Please select a file or files to be edited.

Edit license

For selected file(s) set a license to

Select File(s)

Please select a file or files to be downloaded.

Select File(s)

Please select a file or files for access request.

Select File(s)

Please select restricted file(s) to be unrestricted.

Request Access

  You need to Log In/Sign Up to request access to this file.

Continue
Dataset Terms

Please confirm and/or complete the information needed below in order to continue.

Asterisks indicate required fields

Request Access

Access to file(s) subject to additional consent under following conditions:

Accept
Package File Download
Restricted Files Selected

The restricted file(s) selected may not be downloaded because you have not been granted access.

Restricted Files Selected

The restricted file(s) selected may not be downloaded because you have not been granted access.

Click Continue to download the files you have access to download.

Delete Dataset

Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.

Embargo

Embargo

Are you sure you want to lift the embargo?

Once you lift the embargo, you will not be able to set it again.

Delete Draft Version

Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.

Dataset Private URL

Use a Private URL to allow those without Dataverse accounts to access your dataset. For more information about the Private URL feature, please refer to the User Guide.

Private URL has not been created.

Dataset Private URL

Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your dataset.

Submit for Review

You will not be able to make changes to this dataset while it is in review.

Submit
Publish Dataset

This dataset cannot be published until Mossakowski Medical Research Institute PAS (Polska Akademia Nauk) is published. Would you like to publish both right now?

Once you publish this dataset it must remain published.

Publish Dataset

Are you sure you want to republish this dataset?

Select if this is a minor or major version update.

Publish Dataset

This dataset cannot be published until Mossakowski Medical Research Institute PAS (Polska Akademia Nauk) is published by its administrator.

Publish Dataset

This dataset cannot be published until Mossakowski Medical Research Institute PAS (Polska Akademia Nauk) and RepOD are published.

Return for modification


Send a copy of this message to the return e-mail address.
OK
Deaccession Dataset

Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.