If you don't see your institution, add your dataset to the main dataverse named "RepOD".
Select the dataverse to which you want to add the new dataset:
You need to Sign In/Sign Up to add a dataset.
Share this dataset on your favorite social media networks.
Łojkowski, Witold, 2025, "Enhanced killing of colon cancer cells by mesoporous silica nanoparticles loaded with ellagic acid", https://doi.org/10.18150/WAGB4E, RepOD, V1
Learn about Data Citation Standards.
Abstract: Natural compounds, including ellagic acid (ELG), have potentially a great antitumor efficacy with low adverse effects. However, their efficacy needs to be improved Nanotechnology permits to create nanoparticles as natural drug carriers and improve their in cancer therapy. We report an inorganic-organic nanostructure composed of mesoporous silica nanoparticles (MSN) functionalized with triptycene (TRP) and loaded with ELG, further called MSN-TRP-ELG nanoformulation. The nanoformulation contained over 11 wt.% TRP and approximately 25 wt.% ELG. It was tested for anticancer effects against two colon cancer cells: HCT-116 and HT-29 for treatment with up to 200 µM. Comparing to free ELG, we have shown a 3 times higher cancer inhibition. The lowest IC50 values were for HCT-116 (88.1±0.1 µM) and HT-29 (77.6±0.1 µM). When treated with free ELG the values were 187.1±0.10µM, and 300.0±0.07 µM, respectively. MSN-TRP-ELG enhanced cell death apoptosis primally via activating caspase-3, p53 and Bax. It also inhibited receptor tyrosine kinases (HER2 and VEGFR2) and upregulated Bcl-2 in HCT-116 and HT-29 cells. An important finding was that B-RAF CRAF and K-RAS were inhibited. The expression of B-RAF, C-RAF, and K-RAS oncogenes was also highly inhibited by the nanoformulation compared to free ELG. This research confirms the potential of nanomedicine for enhancing the efficiency in application of natural prodrugs, and in. particular ELG in cancer therapy and opens the way for further preclinical research.
nanoparticles, drug delivery, cancer, ellagic acid, prodrug
CC0 Creative Commons Zero 1.0
Select all 11 files in this dataset.
Please select a file or files to be deleted.
The file(s) will be deleted after you click on the Delete button.
Files will not be removed from previously published versions of the dataset.
Please select a file or files to be edited.
For selected file(s) set a license to
Please select a file or files to be downloaded.
Please select a file or files for access request.
Please select restricted file(s) to be unrestricted.
You need to Log In/Sign Up to request access to this file.
Please confirm and/or complete the information needed below in order to continue.
Asterisks indicate required fields
Access to file(s) subject to additional consent under following conditions:
The restricted file(s) selected may not be downloaded because you have not been granted access.
Click Continue to download the files you have access to download.
Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.
Are you sure you want to lift the embargo?
Once you lift the embargo, you will not be able to set it again.
Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.
Use a Private URL to allow those without Dataverse accounts to access your dataset. For more information about the Private URL feature, please refer to the User Guide.
Private URL has not been created.
Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your dataset.
You will not be able to make changes to this dataset while it is in review.
This dataset cannot be published until Institute of High Pressure Physics is published. Would you like to publish both right now?
Once you publish this dataset it must remain published.
Are you sure you want to republish this dataset?
Select if this is a minor or major version update.
This dataset cannot be published until Institute of High Pressure Physics is published by its administrator.
This dataset cannot be published until Institute of High Pressure Physics and RepOD are published.
Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.
Contact person for this dataset, having substantive knowledge of the data
Please fill this out to prove you are not a robot.
