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Witucki, Łukasz; Jakubowski, Hieronim, 2026, "Association of Cbs with Alzheimer’s disease in mice and N2a-APPswe cells", https://doi.org/10.18150/JU6BWR, RepOD, V1
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The dataset contains western blot and real-time PCR results of mTOR and autophagy markers performed in mouse brain and in N2A-APPswe cells treated with homocysteine metabolites and after Cbs and Phf8 silencing. Confocal microscope analysis of amyloid beta aggregation after silencing of Cbs and Phf8 or after treatments with homocysteine metabolites were collected. CHIP results of mTOR occupancy by H4K20me1 were generated by RT-qPCR method.
amyloid beta, APP, autophagy, Cbs-/- mouse, H4K20me1, homocysteine thiolactone, mTOR signaling, N-homocysteinylated protein, Phf8
Łukasz Witucki, Ł., Jakubowski, H. Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice. Journal of Inherited Metabolic Disease. Vol. 46, Issue6 https://doi.org/10.1002/jimd.12661 https://doi.org/10.1002/jimd.12661 doi: 10.1002/jimd.12661
2029-02-16
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