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Rydz, Joanna, 2024, "Research data for the publication 'Oligopeptide-based molecular labelling of (bio)degradable polyester biomaterials'", https://doi.org/10.18150/IKMKN6, RepOD, V1
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Nowadays, a very important motivation for the development of new functional materials for medical purposes is not only their performance but also whether they are environmentally friendly. In recent years, there has been a growing interest in the possibility of labelling (bio)degradable polymers, in particular those intended for specific applications, especially in the medical sector, and the potential of information storage in such polymers, making it possible, for example, to track the ultimate environmental fate of plastics. The dataset shows the analyzes that led to the development of a straightforward green approach that combines both aspects using an oligopeptide, which is an integral part of polymer material, to store binary information in a physical mixture of polymer and oligopeptide. In the proposed procedure the year of production of polymer films made of poly(L-lactide) (PLLA) and a blend of poly(1,4-butylene adipate-co-1,4-butylene terephthalate) and polylactide (PBAT/PLA) were encoded as the sequence of the appropriate amino acids in the oligopeptide (PEP) added to these polymers. The decoding of the recorded information was carried out using mass spectrometry technique as a new method of decoding, which enabled the successful retrieval and reading of the stored information. Furthermore, the properties of labelled (bio)degradable polymer films and stability during biodegradation of PLLA/PEP film under industrial composting conditions have been investigated. The labelled films exhibited good oligopeptide stability, allowing the recorded information to be retrieved from a green polymer/oligopeptide system before and after biodegradation. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay) study of the PLLA and PLLA/PBAT using the MRC-5 mammalian fibroblasts was presented for the first time.
All explanations of research procedures, methodologies and analyzes are described in the Raw_data_Labelling.odt file.
Obecnie bardzo ważną motywacją do opracowywania nowych materiałów funkcjonalnych do celów medycznych jest nie tylko ich wydajność, ale także to, czy są przyjazne dla środowiska. W ostatnich latach rośnie zainteresowanie możliwością znakowania polimerów (bio)degradowalnych, w szczególności przeznaczonych do określonych zastosowań, zwłaszcza w sektorze medycznym, oraz potencjałem przechowywania informacji w takich polimerach, dzięki czemu możliwe jest m.in. śledzenie ostatecznego losu tworzyw sztucznych w środowisku. Zbiór danych przedstawia analizy, które doprowadziły do opracowania prostego podejścia, które łączy oba aspekty przy użyciu oligopeptydu, który jest integralną częścią materiału polimerowego, do przechowywania informacji binarnej w fizycznej mieszaninie polimeru i oligopeptydu. W proponowanej procedurze rok produkcji folii polimerowych wykonanych z poli(L-laktydu) (PLLA) oraz mieszanki poli(adypinianu 1,4-butylenu-co-1,4-tereftalanu butylenu) i polilaktydu (PBAT/PLA) ) zostały zakodowane jako sekwencja odpowiednich aminokwasów w oligopeptydzie (PEP) dodanym do tych polimerów. Do dekodowania zarejestrowanych informacji wykorzystano technikę spektrometrii mas, będącą nową metodą dekodowania, która umożliwiła skuteczne odtworzenie i odczytanie przechowywanych informacji. Ponadto zbadano właściwości znakowanych (bio)degradowalnych folii polimerowych oraz stabilność podczas biodegradacji folii PLLA/PEP w warunkach kompostowania przemysłowego. Znakowane filmy wykazywały dobrą stabilność oligopeptydów, umożliwiając odzyskanie zarejestrowanych informacji z układu polimer/oligopeptyd przed i po biodegradacji. Po raz pierwszy zaprezentowano badanie MTT (3-(4,5-dimetylotiazol-2-ilo)-2,5-difenylo-2H-tetrazolium bromek assay) z wykorzystaniem fibroblastów ssaków MRC-5 dla PLLA i PLLA/PBAT.
Wszystkie objaśnienia procedur badawczych, metodologii i analiz są opisane w pliku Raw_data_Labelling.odt.
polyester, poly(1,4-butylene adipate-co-1,4-butylene terephthalate), polylactide, labelling, identification, macromolecular information storage, peptide, poliester, poli(adypinian 1,4-butylenu-ko-1,4-tereftalan butylenu), polilaktyd, etykietowanie, identyfikacja, przechowywanie informacji, peptyd
Rydz J, Duale K, Sikorska W, Musioł M, Janeczek H, Marcinkowski A, Siwy M, Adamus G, Mielczarek P, Silberring J, Juszczyk J, Piętka E, Radecka I, Gupta A, Kowalczuk M. Oligopeptide-based molecular labelling of (bio)degradable polyester biomaterials. Int J Biol Macromol. 2024:131561. https://doi.org/10.1016/j.ijbiomac.2024.131561 https://doi.org/10.1016/j.ijbiomac.2024.131561 doi: 10.1016/j.ijbiomac.2024.131561
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