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Czapski, Grzegorz, 2025, "Data related to manuscript: BET protein inhibitor JQ1 reduces inflammation and hippocampal amyloid-β level without altering Tau phosphorylation in LPS-challenged adult wild-type mice", https://doi.org/10.18150/I3B5JT, RepOD, V2
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Data related to manuscript: BET protein inhibitor JQ1 reduces inflammation and hippocampal amyloid-β level without altering Tau phosphorylation in LPS-challenged adult wild-type mice.
These data were used to create Figures 1-6.
Figure 1 presents the effect of JQ1 on sickness behavior after LPS-evoked systemic inflammation in mice up to 12 h post-injection.
Figure 2 presents the effect of JQ1 on cytokine levels in blood serum 3 and 12 h after LPS-evoked systemic inflammation.
Figure 3 presents the effect of LPS-evoked systemic inflammation on the level of BET proteins in the murine hippocampus 12 h post-injection.
Figure 4 presents the effect of LPS and JQ1 on the expression of inflammation-related genes in hippocampus 3 and 12 h post-injection.
Figure 5 presents the effect of JQ1 on Tau level and phosphorylation in the hippocampus 12 h after LPS-evoked systemic inflammation.
Figure 6 presents the effect of JQ1 on Amyloid-β level in the hippocampus 12 h after LPS-evoked systemic inflammation.
Figure 7 presents the effect of JQ1 on the expression of inflammation-related genes in hippocampus 3 and 12 h post-injection.
mice, Lipopolysaccharides, Inflammation, Hippocampus, Amyloid
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