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Witucki, Łukasz; Jakubowski, Hieronim, 2026, "Phf8's effect on autophagy via microRNA", https://doi.org/10.18150/FKM7KU, RepOD, V1
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The dataset contains the result of the influence of homocysteine, homocysteine thiolactone and N-homocysteinylated protein on the autophagy process via PHF8. The dataset contains data from RT-qPCR and WB quantification after cells treated with specific microRNA inhibitor which regulates autophagy process, homocysteine, homocysteine thiolactone and N-homocysteinylated protein. HUVEC cells were used in those experiments. Hearts of Cbs deficient mice were used as in-vitro model.
Phf8, homocysteine metabolites, microRNA, autophagy, endothelial dysfunction
Witucki, Ł., Jakubowski, H. Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice. The FASEB Journal. Vol. 38, Issue 18 https://doi.org/10.1096/fj.202302116R https://doi.org/10.1096/fj.202302116R doi: 10.1096/fj.202302116R
2029-03-26
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