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Smolińska, Agnieszka, 2026, "Analysis of stem-like and neural-like properties of CD271+ subpopulation obtained from Wharton jelly derived mesenchymal stem/stromal cells", https://doi.org/10.18150/D7EMSF, RepOD, V1
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The main objective of this study was to determine whether CD271+ cells within the Wharton Jelly derived mesenchymal stromal cell (WJ-MSC) population exhibit an enhanced capacity to differentiate into neural-like cells. Fluorescence-activated cell sorting (FACS) was used to distinguish and separate cells expressing the CD271 antigen, resulting in two populations being obtained: negative (WJ-MSC-CD271-) and positive (WJ-MSC-CD271+). Firstly, the initial negative and positive populations were characterised in terms of their self-renewal potential and expression of neuronal and glial markers by quantitative RT-PCR or immunocytochemistry (ICC). We also examined the dynamics of the CD271+ cells in subsequent WJ-MSC in vitro cultures for the next two passages after FACS. Secondly, cells from the negative and positive populations were cultured with nervous tissue components, such as cerebrospinal fluid (CSF), or fragments of native tissue in an organotypic hippocampal slice culture (OHC). After coculture, examination of the expression of the aforementioned markers was repeated. In this way, we hope to clarify whether the presence of the CD271 antigen predicts better cell differentiation capability, and whether the selected MSC subpopulation could serve as a pool of neural progenitor cells for nervous system therapies.
mesenchymal stem cells, CD271, neural differentiation
CD271 identifies a subpopulation with enhanced neural-like potential within Wharton Jelly derived mesenchymal stem/stromal cells doi:
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