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Cyclodextrin/PVP-based nanofibers with Rhadiola rosea extract as a new concept for increasing bioavailability of active components

Version 1.0

Paczkowska-Walendowska, Magdalena, 2025, "Cyclodextrin/PVP-based nanofibers with Rhadiola rosea extract as a new concept for increasing bioavailability of active components", https://doi.org/10.18150/ZT5PZI, RepOD, V1

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Description

Dissolution_rosarin.xlsx - data represent the percentage of rosarin released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Nanofibers were placed in 30 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://www.mdpi.com/1420-3049/30/16/3359) and converted, relative to the weight, into the percentage of the substance released during the experiment.

Dissolution_salidroside.xlsx - data represent the percentage of salidroside released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Nanofibers were placed in 30 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://www.mdpi.com/1420-3049/30/16/3359) and converted, relative to the weight, into the percentage of the substance released during the experiment.

Subject
Medicine, Health and Life Sciences
Keyword

nanofibers, rhadiola, dissolution

Related Publication

Jaskólski, M.; Paczkowska-Walendowska, M.; Rybarczyk, Z.; Rosiak, N.; Miklaszewski, A.; Cielecka-Piontek, J. Cyclodextrin/PVP-Based Nanofibers with Rhadiola rosea Extract as a New System for Increasing Bioavailability of Active Components. Molecules 2025, 30, 3359. https://doi.org/10.3390/molecules30163359 https://doi.org/10.3390/molecules30163359 doi: 10.3390/molecules30163359

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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Dissolution_rosarin.tab
Tabular Data - Original format: MS Excel (XLSX) - 695 B - Nov 28, 2025 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
17 Variables, 6 Observations - UNF:6:dssyqU/o86Bj1UFgGnyQRA==
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Dissolution_salidroside.tab
Tabular Data - Original format: MS Excel (XLSX) - 720 B - Nov 28, 2025 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
17 Variables, 7 Observations - UNF:6:5QUO+9uPU5mP3rIpUp/hWw==
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