Stability and shaking tests of agomelatine coated microneedles (MNs).
Three different shapes of microneedles were analyzed:
- rockets
- pyramids
- arrow.
In addition, 3 different 3D printing methods have been used:
- DLP
- FMD
- resin with 3% agomelatine mixed in.
Max. the solubilities of agomelatine (powder) were determined by shaking (32°C, 200rpm) in:
- dissolution buffer (1:25), pH=7.4
- dissolution buffer (1:25), pH=7.4 + 40% EtOH
- 40% EtOH
To check the stability of the samples after release performed on diffusion Franz cells, random samples were subjected to HPLC re-analysis several days after the first analysis. The results were compared.
The set contains data in text file format and LCD format, , created using the LabSolutions software (HPLC, Nexera LC 2040C).