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Sęk, Sławomir; Pułka-Ziach, Karolina; Bachurska-Szpala, Paulina; Burdach, Kinga; Lasek, Robert; Tymecka, Dagmara; Juhaniewicz-Dębińska, Joanna; Bartosik, Dariusz, 2023, "Physicochemical and biological characterization of helicomimetic lipooligoureas", https://doi.org/10.18150/NFUXKW, RepOD, V1
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New class of foldamer-based mimetics of lipopeptides, called lipooligoureas has been demonstrated including synthesis and physicochemical as well as biological characterization. Lipooligoureas display antimicrobial activity and inhibit the growth of MRSA strains. They also show increased stability against proteolytic degradation in human blood serum. Structural differences in oligourea moiety determine their aggregation behavior and the aggregation ability correlates with antimicrobial activity.
peptidomimetic foldamers, oligourea, antimicrobial compounds, lipooligoureas
Paulina Bachurska-Szpala, Kinga Burdach, Robert Lasek, Dagmara Tymecka, Joanna Juhaniewicz-Dębińska, Dariusz Bartosik, Karolina Pułka-Ziach, Sławomir Sęk "De novo designed self-assembling helicomimetic lipooligoureas with antibacterial activity" European Journal of Medicinal Chemistry Volume 259, 5 November 2023, 115700. https://doi.org/10.1016/j.ejmech.2023.115700 doi: 10.1016/j.ejmech.2023.115700
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