If you don't see your institution, add your dataset to the main dataverse named "RepOD".
Select the dataverse to which you want to add the new dataset:
You need to Sign In/Sign Up to add a dataset.
Share this dataset on your favorite social media networks.
Gliźniewicz, Marta, 2025, "Effects of sequential administration of phage cocktail, ciprofloxacin, and caspofungin on Staphylococcus aureus and Candida albicans dual species biofilms", https://doi.org/10.18150/KBUVE0, RepOD, V1
Learn about Data Citation Standards.
Polymicrobial biofilms, are another threat in the post-antibiotic era. Staphylococcus aureus and Candida albicans often occur together, causing infections that are difficult to treat. Therefore, many alternative solutions are investigated, including phage antibiotic synergy (PAS), which may be more effective because of different mechanisms of action. In this work, we investigated how different sequences of administration phage cocktail, ciprofloxacin, and caspofungin will eradicate S. aureus/ C. albicans in liquid culture and biofilm. In liquid culture, the sequence of phages then caspofungin then ciprofloxacin completely eradicated S. aureus and C. albicans. In the case of biofilm, the best therapeutic option was the administration of three agents at once or using phages and ciprofloxacin before caspofungin.
In conclusion, phages must first be administrated alone or with other factors in both environments. Sequences, when both drugs or only caspofungin was first introduced to cultures, were less effective. The sequence of administration of drugs and phages should be taken into account when planning alternative therapies based on their synergistic action.
There are several readme files attached to this dataset, where more information is presented.
phage therapy, phage antibiotic synergy (PAS), drug resistance, polymicrobial biofilm
CC0 Creative Commons Zero 1.0
Select all 14 files in this dataset.
Please select a file or files to be deleted.
The file(s) will be deleted after you click on the Delete button.
Files will not be removed from previously published versions of the dataset.
Please select a file or files to be edited.
For selected file(s) set a license to
Please select a file or files to be downloaded.
Please select a file or files for access request.
Please select restricted file(s) to be unrestricted.
You need to Log In/Sign Up to request access to this file.
Please confirm and/or complete the information needed below in order to continue.
Asterisks indicate required fields
Access to file(s) subject to additional consent under following conditions:
The restricted file(s) selected may not be downloaded because you have not been granted access.
Click Continue to download the files you have access to download.
Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.
Are you sure you want to lift the embargo?
Once you lift the embargo, you will not be able to set it again.
Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.
Use a Private URL to allow those without Dataverse accounts to access your dataset. For more information about the Private URL feature, please refer to the User Guide.
Private URL has not been created.
Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your dataset.
You will not be able to make changes to this dataset while it is in review.
This dataset cannot be published until RepOD is published. Would you like to publish both right now?
Once you publish this dataset it must remain published.
Are you sure you want to republish this dataset?
Select if this is a minor or major version update.
This dataset cannot be published until RepOD is published by its administrator.
This dataset cannot be published until RepOD and are published.
Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.
Contact person for this dataset, having substantive knowledge of the data
Please fill this out to prove you are not a robot.
