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Wrocław University of Science and Technology

(Politechnika Wrocławska)

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Cationic bilosomes as novel nanoplatform for skin melanoma treatment

Version 1.0

Bazylińska, Urszula, 2026, "Cationic bilosomes as novel nanoplatform for skin melanoma treatment", https://doi.org/10.18150/YJTM8U, RepOD, V1

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Description

This comprehensive collection contains data related to the development and biological evaluation of cationic bilosome-based nanosystems for targeted treatment of melanoma. To this end, bilosomal carriers were co-loaded with the photosensitizer Rose Bengal (RB) and natural compound astaxanthin (AST) to enhance the efficacy of photodynamic therapy (PDT).

This research was conducted as part of the SONATA BIS 13 project (grant number 2023/50/E/ST4/00603), which is titled "Designing and microfluidic synthesis of hybrid nanocarriers stabilized by novel sugar-based surfactants as a potential “green" anticancer platform”. The project was funded by the National Science Centre in Poland. The study involved detailed physicochemical characteristics and extensive in vitro analysis of human melanoma cell lines (A375 and Me45) and healthy human keratinocytes (HaCaT).

The set of data contains:

1. DLS (Dynamic Light Scattering) and ELS (Electrophoretic Light Scattering) data associated with hydrodynamic diameters, polydispersity index, and zeta potential, including a 30-day storage stability study.

2. Transmission Electron Microscopy (TEM) images confirming the morphology of empty and drug-loaded bilosomes.

3. Singlet Oxygen Generation (SOG) efficiency data, including kinetic calculations and raw spectral measurements using the ABMDMA fluorescent probe.

4. UV-Vis spectroscopic data covering spectral characterization, photobleaching resistance, biological stability in various media, and in vitro drug release profiles at physiological (7.4) and acidic (5.5) pH.

5. Cellular uptake analysis obtained via flow cytometry (quantitative) and fluorescence microscopy (qualitative).

6. Advanced bioimaging data from Holotomographic Microscopy (HTM), providing 2D refractive index maps and 3D volumetric reconstructions of treated cells.

7. In vitro cytotoxicity results (MTT assay) documenting the safety profile (dark cytotoxicity) and phototherapeutic effectiveness (phototoxicity) of the systems.

(2025-02-12)

Subject

Chemistry

Keyword

lipid-based nanovesicular systems, bile salts, Rose Bengal, astaxanthin, antitumor activity, phyto-photodynamic therapy

Related Publication

Ewelina Waglewska, Julita Kulbacka, Urszula Bazylińska, 2025, Harnessing Cationic Bilosomes to Create a Green Light-Triggered Nanoplatform for Skin Melanoma Treatment, Nanotechnology, Science and Applications, 18, 423-443 https://doi.org/10.2147/NSA.S531026 doi: 10.2147/NSA.S531026

License

CC0 Creative Commons Zero 1.0

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1 to 9 of 9 Files

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		01_DLS_ELS.rar Unknown - 20.7 KB - Jul 17, 2026 - 0 Downloads MD5: 449f272bf196f5e3ff4abc8a7a00b1b3 License: CC0 Creative Commons Zero 1.0 DLS and ELS data associated with hydrodynamic diameters, polydispersity index, and zeta potential, including a 30-day storage stability study	Download
		02_TEM.rar Unknown - 2.8 MB - Jul 17, 2026 - 0 Downloads MD5: 909728ab941f2e5e8ef37dc1817fc9a3 License: CC0 Creative Commons Zero 1.0 TEM images confirming the morphology of empty and drug-loaded bilosomes	Download
		03_Singlet_Oxygen_Generation.rar Unknown - 84.9 KB - Jul 17, 2026 - 0 Downloads MD5: 8a358239dc57684edf0517f2ca148564 License: CC0 Creative Commons Zero 1.0 SOG efficiency data, including kinetic calculations and raw spectral measurements using the ABMDMA fluorescent probe	Download
		04_UV_VIS.rar Unknown - 121.7 KB - Jul 17, 2026 - 0 Downloads MD5: a401d21221d35610274a191441c333c7 License: CC0 Creative Commons Zero 1.0 UV-Vis spectroscopic data covering spectral characterization, photobleaching resistance, biological stability in various media, and in vitro drug release profiles at physiological (7.4) and acidic (5.5) pH	Download
		05_Cellular_Uptake_Flow_Cytometry.rar Unknown - 168.3 KB - Jul 17, 2026 - 0 Downloads MD5: 4e7cd52b225cea6f43ed292acfa8cb43 License: CC0 Creative Commons Zero 1.0 Cellular uptake analysis obtained via flow cytometry (quantitative)	Download
		06_Cellular_Uptake_FM.rar Unknown - 2.1 MB - Jul 17, 2026 - 0 Downloads MD5: 0e45b32b53a4993c475811e2d33e0ef7 License: CC0 Creative Commons Zero 1.0 Cellular uptake analysis obtained via fluorescence microscopy (qualitative)	Download
		07_Bioimiging_Study_HTM.rar Unknown - 744.0 KB - Jul 17, 2026 - 0 Downloads MD5: a83c966fff8a8a748f804eae1dc8497e License: CC0 Creative Commons Zero 1.0 Advanced bioimaging data from Holotomographic Microscopy (HTM), providing 2D refractive index maps and 3D volumetric reconstructions of treated cells	Download
		08_Dark_Cytotoxicity_MTT.rar Unknown - 12.9 KB - Jul 17, 2026 - 0 Downloads MD5: f27eecb2ab148bdac97cdd7461980ac1 License: CC0 Creative Commons Zero 1.0 In vitro cytotoxicity results (MTT assay) documenting the safety profile (dark cytotoxicity) of the nanosystems upon A375, Me45, HaCaT cell lines	Download
		09_Photo_Cytotoxicity_MTT.rar Unknown - 10.8 KB - Jul 17, 2026 - 0 Downloads MD5: c9b91a795387111561f99b834101444e License: CC0 Creative Commons Zero 1.0 In vitro photocytotoxicity results (MTT assay) documenting the photodynamic activity of the nanosystems upon A375, Me45, HaCaT cell lines	Download

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