The dataset contains the experimental data files generated based on the publication entitled “Eutectic Coamorphous System of Enzalutamide and Acetyl Maltose: A Strategy for Improved Physical Stability and Aqueous Solubility.” The study focused on co-amorphous systems composed of enzalutamide (ENZ) and octaacetyl maltose (acMAL), with particular emphasis on the eutectic composition containing 75 wt% acMAL.
The results may be useful for researchers working on amorphous and co-amorphous pharmaceutical systems, eutectic formulations, molecular mobility, physical stability of amorphous drugs, and solubility enhancement strategies for poorly water-soluble active pharmaceutical ingredients.
The submitted DSC data were used to identify the eutectic composition in crystalline ENZ–acMAL mixtures and to determine the glass transition temperatures of amorphous ENZ, acMAL, and their binary co-amorphous systems. In these files, the x axis corresponds to temperature, while the y axis corresponds to heat flow.
The FTIR data were used to investigate intermolecular interactions between ENZ and acMAL. The spectra are presented as a function of wavenumber, with normalized log(1/reflectance) or absorbance/intensity values on the y axis, depending on the processed dataset. These data were used to analyze spectral changes associated with heteromolecular interactions in crystalline, molten, and glassy states.
The broadband dielectric spectroscopy data include dielectric loss spectra of neat ENZ and selected ENZ–acMAL co-amorphous systems. The dielectric loss, ε″, and dielectric permittivity, ε′, were recorded over a broad frequency range at different temperatures. For loss spectra, ε″ is plotted against frequency. These data were used to evaluate the effect of acMAL on the molecular mobility and relaxation dynamics of ENZ.
The dataset also includes isothermal recrystallization data obtained from dielectric measurements. These files contain changes in dielectric response, mainly ε′, as a function of time and were used to assess the physical stability and recrystallization resistance of amorphous ENZ and ENZ–acMAL systems, especially the eutectic ENZ + 75 wt% acMAL formulation.
The dissolution and solubility data include apparent solubility studies and non-sink dissolution experiments performed in aqueous and biorelevant media. In these files, the reported values correspond to the chromatographic peak area, i.e., the area under the ENZ peak, rather than directly calculated concentration values. The peak area was used to quantify the amount of dissolved ENZ based on the calibration curve. These data were used to evaluate the ability of ENZ–acMAL systems to enhance ENZ solubility and maintain supersaturation.
Please consult the Readme.txt file for additional information.
(2026)
