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Estradiol induces global changes in miRNA expression in endometrial cancer cells and upregulates oncogenic miR-182

Version 1.0

Klicka, Klaudia, 2026, "Estradiol induces global changes in miRNA expression in endometrial cancer cells and upregulates oncogenic miR-182", https://doi.org/10.18150/X1KJ3H, RepOD, V1

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Description

The dataset presents data from the article entitled "Estradiol induces global changes in miRNA expression in endometrial cancer cells and upregulates oncogenic miR-182" published in bioRxiv. This study aimed to assess the role of the miRNA-estrogen axis in endometrial cancer cells

The dataset presents calculations of relative expression of selected miRNAs which expression was most strongly induced by estradiol in endometrial cancer cells, the expression of selected microRNAs in dissected tissue of endometrial cancer and healthy endometrium, the proliferation of mimic miR-182-transfected 213 Ishikawa cells compared to control, and the relative expression of selected targets in mimic miR-182 and anti-miR-182 -transfected Ishikawa cells.

(2025-11-18)
Subject
Medicine, Health and Life Sciences
Keyword

endometrial cancer, microRNA

Related Publication

Klicka, K., et al. (2024). "Estradiol induces global changes in miRNA expression in endometrial cancer cells and upregulates oncogenic miR-182." bioRxiv: 2024.2005.2012.593753, https://doi.org/10.1101/2024.05.12.593753 https://doi.org/10.1101/2024.05.12.593753 doi: 10.1101/2024.05.12.593753

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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readme.odt
Unknown - 34.5 KB - Jan 22, 2026 - 1 Download
MD5: bac948c67836373c02cc3b42a9d8005e
License: CC BY - Creative Commons Attribution 4.0
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readme.docx
MS Word (docx) - 16.1 KB - Jan 22, 2026 - 0 Downloads
MD5: 382c12c1f61079425ac8e16da61c60b0
License: CC BY - Creative Commons Attribution 4.0
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fig_2_microRNA_expression_in_EC_and_HE.pzfx
Unknown - 323.9 KB - Jan 22, 2026 - 0 Downloads
MD5: bd97f43f2841cd965ddf4935110b671a
License: CC BY - Creative Commons Attribution 4.0
The expression of miR-182, miR-15a, 197, miR-16, miR-27b, miR-28-3p, miR-29c, miR-31#, miR-92a, miR-106a, miR-106b, 198, miR-129, miR-129-3p, miR-130a, miR-140, miR-140-3p, miR-141, miR-150, 199 miR-152, miR-192, miR-198, miR-200c, miR-215, miR-335, miR-496, miR-517c, 200 and miR-656 in dissected tissue of endometrial cancer and healthy endometrium. U6 was used as an endogenous control. GraphPad Prism 9.1 (GraphPad Software Inc.) was used for statistical analyses using the Kruskal-Wallis and paired t-test. The data can be opened using the Graphpad program, which is available in a 30-day free trial version.
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Fig_3_Proliferation_assay_results.pzfx
Unknown - 54.5 KB - Jan 22, 2026 - 0 Downloads
MD5: 7be45897e073061588e56310d1e09593
License: CC BY - Creative Commons Attribution 4.0
Fig 3. The proliferation of mimic miR-182-transfected Ishikawa cells and anti-miR-182 transfected Ishikawa cells compared to control cells. GraphPad Prism 9.1 (GraphPad Software Inc.) was used for statistical analyses using the Kruskal-Wallis and paired t-test. The data can be opened using the Graphpad program, which is available in a 30-day free trial version.
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Fig_4_The_relative_expression_of_selected_targets_in_Ishikawa_cells.pzfx
Unknown - 440.8 KB - Jan 22, 2026 - 0 Downloads
MD5: e23c91ddcc955a2949f64b1b753d5244
License: CC BY - Creative Commons Attribution 4.0
The relative expression of selected targets (SMAD4, BCL2, COX2, ERα, ESRR1, EZH2, FN1, FOS, FOXA1, MARK1, MCL1, MMP9, NOTCH, PDL1, PFN, PTEN, RECK, TIM2, TIMP3, TP53, TWIST, VIM, ZBTB4, ZEB1) in mimic miR-182 and anti-miR-182-transfected Ishikawa cells compared to control miR-scramble-transfected Ishikawa cells. GraphPad Prism 9.1 (GraphPad Software Inc.) was used for statistical analyses using the Kruskal-Wallis and paired t-test. The data can be opened using the Graphpad program, which is available in a 30-day free trial version.
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Array_A_Table_4_Relative_expression_of_microRNAs_induced_by_estradiol.tab
Tabular Data - Original format: MS Excel (XLSX) - 107.4 KB - Jan 22, 2026 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
19 Variables, 384 Observations - UNF:6:TMeXdwBvZdpZiBtZwcHI8A==
Table 4. Relative expression of miRNAs induced by estradiol in EC cells. Ishikawa EC cells were incubated with estradiol. The expression of miRNAs was assessed using microarray method (Array A). R = 2-ΔΔCt. The experiments were conducted in triplicates.
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Array_B_Table_4_Relative_expression_of_microRNAs_induced_by_estradiol.tab
Tabular Data - Original format: MS Excel (XLSX) - 107.4 KB - Jan 22, 2026 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
19 Variables, 384 Observations - UNF:6:TMeXdwBvZdpZiBtZwcHI8A==
Table 4. Relative expression of miRNAs which expression was most strongly induced by estradiol in EC cells. Ishikawa EC cells were incubated with estradiol. The expression of miRNAs was assessed using microarray method. Array B. R = 2-ΔΔCt. The experiments were conducted in triplicates.
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