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Oćwieja, Magdalena, 2026, "Data related to the work entitled "Polyphenol-Derived Silver and Platinum Nanoparticles Induce Oxidative Stress in N2a Neuroblastoma Cells Despite Antioxidant Precursors"", https://doi.org/10.18150/WP3LKX, RepOD, V1
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Numerous studies have demonstrated that the surface properties of silver (AgNPs) and platinum (PtNPs) nanoparticles play a critical role in modulating biological activity. Considering that polyphenols exhibit biocidal properties and possess strong antioxidant activity, it was hypothesized that the use of gallic acid (GA) and rosmarinic acid (RA) in nanoparticle synthesis could modulate nanoparticle toxicity toward a model mouse neuroblastoma cell line (N2a). PtNPs were synthesized using sodium borohydride, whereas AgNPs were formed using only polyphenols, without additional reducing agents. Each type of nanoparticle exhibited a quasi-spherical shape, a negative surface charge, and long-term stability, as confirmed by dynamic light scattering (DLS) measurements and analysis of the metal ion release profile using inductively coupled plasma optical emission spectrometry (ICP-OES). Spectroscopic studies conducted using surface-enhanced Raman spectroscopy (SERS) and UV-Vis spectroscopy revealed that the stabilizing layers of the nanoparticles were not composed of pure GA and RA molecules but were enriched with their oxidized forms. Biological results showed that, at the investigated concentrations, polyphenols increased cell viability, whereas AgNPs and PtNPs reduced viability after 48 hours of treatment, causing membrane damage and oxidative stress. AgNPs induced stronger oxidative effects than PtNPs, particularly RA-AgNPs. Despite the use of polyphenols with antioxidant activity, AgNPs retained pro-oxidant activity, likely due to polyphenol degradation during synthesis, as confirmed by spectroscopic studies. These findings indicate that the chemical reactions occurring during the synthesis of metal nanoparticles alter the chemical structure of polyphenols. Consequently, the biological properties of GA and RA are not preserved in the nanoparticles.
silver nanoparticles; platinum nanoparticles; gallic acid; rosmarinic acid; polyphenols; cytotoxicity; surface modification; neuroblastoma cells; N2a cells
CC0 Creative Commons Zero 1.0
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