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Expression patterns of MOTS-c in adrenal tumors. Results from a preliminary study

Version 1.0

Rucinski, Marcin, 2025, "Expression patterns of MOTS-c in adrenal tumors. Results from a preliminary study", https://doi.org/10.18150/VWZ0TW, RepOD, V1

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Description

Experimental data from a published article titled "Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study" The collection includes data for analyzing MOTS-c expression in human adrenal glands at both the mRNA level (using the QPCR method) and the protein level (using tissue microarray and immunohistochemistry). It also contains measurements of MOTS-c levels in patients with adrenocortical carcinoma compared to controls.

(2025-03)
Subject
Medicine, Health and Life Sciences
Keyword

MOTS-c, adrenal tumors, mitochondria homeostasis

Related Publication

Kamiński, K., Blatkiewicz, M., Szyszka, M., Olechnowicz, A., Komarowska, H., Klimont, A., Wierzbicki, T., Karczewski, M., Ruchała, M., & Rucinski, M. (2024). Expression Patterns of MOTS-c in Adrenal Tumors: Results from a Preliminary Study. International Journal of Molecular Sciences, 25(16), 8721. https://doi.org/10.3390/ijms25168721 https://doi.org/10.3390/ijms25168721 doi: 10.3390/ijms25168721

CC0 Creative Commons Zero 1.0 CC0 Creative Commons Zero 1.0

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1 to 3 of 3 Files
Elisa.tab
Tabular Data - Original format: MS Excel (XLSX) - 3.6 KB - Oct 6, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
4 Variables, 75 Observations - UNF:6:T6q2xQKrb3w0m2q+1d6w1w==
The dataset contains ELISA measurements of MOTS-c peptide levels in serum samples obtained from patients with adrenal tumors and healthy controls.The dataset includes optical density (OD) values and corresponding calculated concentrations (log-transformed) for four groups: adrenocortical carcinoma (ACC), adrenocortical adenoma (Adenoma), pheochromocytoma, and healthy controls. Each row represents an individual serum sample, with columns providing OD readings, log10-transformed concentrations, and calculated MOTS-c concentrations in pg/mL.
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TMA.tab
Tabular Data - Original format: MS Excel (XLSX) - 23.1 KB - Oct 6, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
18 Variables, 193 Observations - UNF:6:K4I09K+Tv+GNYmTQfQ6GJw==
Metadata and quantitative measurements obtained from a tissue microarray (TMA) including adrenal gland samples. Each row represents a single tissue core identified by its position (e.g., A1, A2, B1, etc.). The columns provide clinical, pathological, and image-derived data. The columns Position and No. correspond to the physical position of the core on the TMA slide and its sequential number. Age and Sex indicate the donor’s demographic information. Organ/Anatomic Site specifies the tissue origin (in this case, adrenal gland), while Pathology diagnosis describes the histopathological classification, such as adrenal cortical adenoma, adenocarcinoma, pheochromocytoma, or hyperplasia. The columns TNM, Grade, and Stage refer to tumor classification parameters, which are left empty or marked with a dash (“-”) when not applicable (for example, in benign lesions). Type indicates whether the sample is benign, malignant, hyperplastic, normal, or adjacent normal adrenal tissue. Additional columns (Tissue ID., Notes) are present in the original TMA template provided by the manufacturer but were not filled in for this dataset. The subsequent columns (lp, area, mean, min, max, and CTCF) contain quantitative image analysis results, including the measurement area, mean intensity, minimum and maximum signal values, and the calculated corrected total cell signal (CTCF).
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QPCR.tab
Tabular Data - Original format: MS Excel (XLSX) - 7.4 KB - Oct 6, 2025 - 0 Downloads
License: CC0 Creative Commons Zero 1.0
6 Variables, 77 Observations - UNF:6:rcuYI2j//sQQOmBE5LGlUw==
Quantitative PCR (qPCR) data evaluating the expression of the Mots-c transcript in different adrenal tissue groups. Each row corresponds to an individual biological sample. The column Group indicates the sample category, including control, ACC (adrenocortical carcinoma), Adenoma, and Pheo (pheochromocytoma). The columns Ct RNU48 and Ct Mots-c represent the raw cycle threshold (Ct) values obtained for the reference gene (RNU48) and the target gene (Mots-c), respectively. The Delta Ct column shows the difference between the Ct values of the target and reference genes (ΔCt = Ct_Mots-c − Ct_RNU48). The Delta Delta Ct column represents the difference between the ΔCt of a given sample and the mean ΔCt of the control group (ΔΔCt = ΔCt_sample − mean ΔCt_control). The final column, 2^−ΔΔCt, indicates the relative expression of Mots-c, normalized to the reference gene and expressed relative to the control samples, calculated according to the 2^−ΔΔCt method.
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