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Rzetecka, Natalia, 2026, "Biomarker discovery in childhood asthma: a pilot study of serum metabolite analysis for IgE-dependent allergy", https://doi.org/10.18150/U1AI9P, RepOD, V1
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This dataset contains experimental data supporting the publication “Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy”. The study was funded by grant no. 2021/43/O/NZ5/00480 from the National Science Centre, Poland
The purpose of the study was to compare metabolite concentrations in serum samples between 13 children with asthma and IgE-dependent allergy and 10 without asthma and IgE-dependent allergy, aged between 6 months and 5 years.
In the study of the 188 metabolites, 131 were determined in the samples and additionally, 48 sums and ratios of metabolites were calculated. Significant differences were found for the 6 metabolites of sphingolipids and glycerophospholipids and the ratio of serotonin synthesis.
The dataset provides comprehensive evidence that serum metabolite concentrations differ between children under five with asthma and IgE-dependent allergy, and children under five without asthma or IgE-dependent allergy. A multiclassifier integrating PC 40:4 and the serotonin synthesis ratio is a promising biomarker for diagnosing childhood asthma accompanied by IgE-dependent allergy.
Asthma, Metabolic Networks and Pathways, Metabolomics, Phosphatidylcholines, Serotonin, Tandem Mass Spectrometry
Rzetecka N, Matysiak J, Plewa S, Matysiak J, Sobkowiak P, Wojsyk-Banaszak I, Bręborowicz A, Pierz W, Klupczyńska-Gabryszak A. Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy. Med Sci Monit. 2025 Jun 24;31:e948478. doi: 10.12659/MSM.948478. PMID: 40554458; PMCID: PMC12207927 https://doi.org/10.12659/msm.948478 doi: 10.12659/MSM.948478
CC0 Creative Commons Zero 1.0
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