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Pruchniewski, Michał, 2025, "Characterization and biological evaluation of electrospun poly-(L-lactide) with GO-AuNPs", https://doi.org/10.18150/TBB7VP, RepOD, V1
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Project Objective: The project aims to establish a supportive scaffold for restoring functional tissue after skin injury by developing an engineered cell-scaffold biointerface using a poly-(L-lactide) (PLLA) scaffold enriched with graphene oxide (GO) and gold nanoparticles (AuNPs).
Scope of Data: The project includes data on microstructural (SEM), elemental (XPS), thermal (TGA+DSC), and mechanical properties of the scaffolds, along with in vitro assessments of biocompatibility (XTT, LDH assay), adhesion (confocal microscopy, SEM, real-time PCR), and regenerative capabilities (protein membrane, histology) using human keratinocytes (HEKa), fibroblasts (HFFF2), and reconstructed epidermis (EpiDerm™).
Tasks Completed:
The findings suggest that the GO-Au composite improved scaffold properties, enhanced cell behaviors, and has potential in skin tissue engineering to regulate cellular fate and prevent hypertrophic tissue formation.
wound healing, electrospun fibers, graphene oxide, gold nanoparticles, proregenerative cell scaffold
Pruchniewski M, Strojny-Cieślak B, Nakielski P, Zawadzka K, Urbańska K, Rybak D, Zakrzewska A, Grodzik M, Sawosz E. Electrospun poly-(L-lactide) scaffold enriched with GO-AuNPs nanocomposite stimulates skin tissue reconstruction via enhanced cell adhesion and controlled growth factors release. Mater. Des. 2025 Feb 11; 251, p.113713 https://www.sciencedirect.com/science/article/pii/S0264127525001339#s0010 doi: https://doi.org/10.1016/j.matdes.2025.113713
CC BY - Creative Commons Attribution 4.0
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