Files include the data presented in the manuscript entitled "Chitosan modified with lanthanum ions as implantable hydrogel for local delivery of bisphosphonates" by M. Jakubowski et al. (https://doi.org/10.1016/j.ijbiomac.2023.123429).
The results concern the characteristics of new osteoporosis drug carriers. Osteoporosis is a disease that affects many people around the world. One group of drugs used to treat it are bisphosphonates. However, they have poor bioavailability and many side effects. Therefore, research around the world is focused on developing bisphosphonate delivery systems. In this work, we would like to present the design of a hydrogel material with chitosan matrix modified with lanthanum, that could serve as an implantable hydrogel capable of sustained and slow release of Zoledronate. Various research techniques were used to characterize the materials, and the swelling ratio was also tested. The conducted research proved that the prepared hydrogel is capable of the long-term release of the Zoledronate. Thanks to this, the prepared material can be successfully used as an implantable hydrogel or a coating on titanium implants for the local delivery of drugs.
Data (.txt) includes:
1) Fig. 6. X-ray diffraction pattern of ChitLa.
2) Fig. 7. FT-IR spectra of ChitLa.
3) Fig. 7. FT-IR spectra of ChitLaZOL.
4) Fig. 9. Swelling ratio.
5) Fig. 10. Raman spectra of chitosan (powder), ChitLa and ChitLaZOL.
6) Fig. 11. Total release of ZOL from the surface of ChitLaZOL sample.
Data (.csv) includes:
1) Fig. 6. X-ray diffraction pattern of ChitLa.(CSV)
2) Fig. 7. FT-IR spectra of ChitLa. (CSV)
3) Fig. 7. FT-IR spectra of ChitLaZOL. (CSV)
4) Fig. 9. Swelling ratio. (CSV)
5) Fig. 10. Raman spectra of chitosan (powder), ChitLa and ChitLaZOL. (CSV)
6) Fig. 11. Total release of ZOL from the surface of ChitLaZOL sample. (CSV)
