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Is it possible to improve the bioavailability of resveratrol and polydatin derived from Polygoni cuspidati radix as a result of preparing electrospun nanofibers based on polyvinylpyrrolidone/cyclodextrin?

Version 1.0

Paczkowska-Walendowska, Magdalena, 2025, "Is it possible to improve the bioavailability of resveratrol and polydatin derived from Polygoni cuspidati radix as a result of preparing electrospun nanofibers based on polyvinylpyrrolidone/cyclodextrin?", https://doi.org/10.18150/SHQRWB, RepOD, V1

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Description

Dissolution_polydatin.xlsx - data represent the percentage of polydatin released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Nanofibers were placed in 300 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://doi.org/10.3390/nu14193897) and converted, relative to the weight, into the percentage of the substance released during the experiment.

Dissolution_resveratrol.xlsx - data represent the percentage of resveratrol released. Columns indicate the systems tested, rows the corresponding time points. Data are presented as a percentage. Dissolution studies of electrospun nanofibers were performed using an Agilent 708-DS dissolution apparatus. A standard basket method was used at 37 ± 0.5 °C with a stirring speed of 50 rpm. Nanofibers were placed in 300 mL of artificial saliva solution at pH 6.8 (potassium chloride (1.20 g), sodium chloride (0.85 g), di-potassium hydrogen orthophosphate (0.35 g), magnesium chloride (0.05 g), calcium chloride (0.20 g), xylitol (20.0 g) and water up to 1 L; pH was adjusted to 6.8 by 1 M HCl). The liquid samples were collected at specified time intervals, and an equal volume of temperature-equilibrated media was replaced. The samples were filtered through a 0.45 μm nylon membrane filter. The concentration was determined using the HPLC method (https://doi.org/10.3390/nu14193897) and converted, relative to the weight, into the percentage of the substance released during the experiment.

Nanofiber weights:

N2: 231,0/ 223,2/ 291,3 mg

N3: 120,1/ 74,2/ 91,3 mg

N4: 244,2/ 218,6/ 271,3 mg

N5: 252,1/ 318,6/ 273,2 mg

N6: 244,1/ 218,6/ 291,3 mg

N9: 236,1/ 264,8/ 243,2 mg

Polydatin/resveratrol content:

N2: 8,29/0,81 ug/1 mg of nanofibers

N3: 6,96/0,81 ug/1 mg of nanofibers

N4: 15,46/1,01 ug/1 mg of nanofibers

N5: 27,46/11,00 ug/1 mg of nanofibers

N6: 18,62/1,78 ug/1 mg of nanofibers

N9: 19,24/2,26 ug/1 mg of nanofibers

Subject
Medicine, Health and Life Sciences
Keyword

nanofibers

Related Publication

Paczkowska-Walendowska, Magdalena, Andrzej Miklaszewski, and Judyta Cielecka-Piontek. 2022. "Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from Polygoni cuspidati Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?" Nutrients 14, no. 19: 3897. https://doi.org/10.3390/nu14193897 https://doi.org/10.3390/nu14193897 doi: 10.3390/nu14193897

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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Dissolution_polydatin.tab
Tabular Data - Original format: MS Excel (XLSX) - 2.0 KB - Oct 16, 2025 - 1 Download
License: CC BY - Creative Commons Attribution 4.0
15 Variables, 11 Observations - UNF:6:iXBqKC1E4M8rAbLVpcHnQQ==
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Dissolution_resveratrol.tab
Tabular Data - Original format: MS Excel (XLSX) - 1.7 KB - Oct 16, 2025 - 2 Downloads
License: CC BY - Creative Commons Attribution 4.0
13 Variables, 11 Observations - UNF:6:+ihW4UHY3DfBjK316A7YeA==
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