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Nencki Institute of Experimental Biology

(Instytut Biologii Doświadczalnej im. Marcelego Nenckiego)

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Research data for study: Anillin level fluctuations during senescence induction and senescence escape in cancer cells

Version 1.0

Staniak, Karolina, 2026, "Research data for study: Anillin level fluctuations during senescence induction and senescence escape in cancer cells", https://doi.org/10.18150/SGOR3H, RepOD, V1

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Description

The files contain research data described in the manuscript entitled: “Anillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence.”

The dataset includes the kinetics of changes in the protein levels of anillin and p53 in breast cancer MCF-7 and colon cancer HCT116 cells induced to senesce by doxorubicin. It also contains a heat map illustrating the levels of anillin and p53 proteins in the analyzed model of senescence escape (MCF-7 and HCT116 cells).

Additionally, the dataset includes an analysis of bromodeoxyuridine incorporation, as well as an assessment of the number of cells exhibiting increased activity of senescence-associated β-galactosidase in MCF-7 and HCT116 cells induced to senesce by doxorubicin.

The dataset is part of a research project investigating the mechanisms underlying cancer cell escape from senescence, funded by the National Science Centre, Poland, under the SONATINA 5 program (grant number 2021/40/C/NZ3/00057).

(2026-04-11)

Subject

Medicine, Health and Life Sciences

Keyword

cancer senescence, anillin

Related Publication

Tomasz Buko , Karolina Staniak , Magdalena Dudkowska , Dorota Janiszewska , Dominika Dębowska , Agnieszka Gadecka , Anna Bielak-Zmijewska. Anillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence. Aging and disease. 2025. https://doi.org/10.14336/AD.2025.0402 https://doi.org/10.14336/AD.2025.0402 doi: 10.14336/AD.2025.0402

License

CC BY - Creative Commons Attribution 4.0

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1 to 10 of 12 Files

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			Original Format Archival Format (.tab)
		metadata.txt Plain Text - 7.0 KB - Apr 13, 2026 - 0 Downloads MD5: 0b622817269ead165c05661c16eed881 License: CC BY - Creative Commons Attribution 4.0 This file contains explanation for raw and processed data used in the dataset.	Preview Download
		fig4c_e_processed_data_western_blot_analysis_HCT116.tab Tabular Data - Original format: MS Excel (XLSX) - 4.3 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 48 Observations - UNF:6:g+aTZNWd1aQT8HpSBt1RaA== Normalized densitometry data corresponding to Fig. 4C and 4E. The dataset contains quantitative analysis of Western blot signals for anillin and p53 proteins in HCT116 cells undergoing doxorubicin-induced senescence.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		fig4c_e_raw_data_western_blot_analysis_HCT116.tab Tabular Data - Original format: MS Excel (XLSX) - 3.4 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 48 Observations - UNF:6:LXXnG5jjLMbfu6wh+GmgEA== Raw densitometry data corresponding to Fig. 4C and 4E. The dataset contains quantitative analysis of Western blot signals for anillin and p53 proteins in HCT116 cells undergoing doxorubicin-induced senescence.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		fig4d_f_processed_data_western_blot_analysis_MCF_7.tab Tabular Data - Original format: MS Excel (XLSX) - 4.3 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 48 Observations - UNF:6:WIhFjjlwLubc16q0dywZ3w== Normalized densitometry data corresponding to Fig. 4D and 4F. The dataset contains quantitative analysis of Western blot signals for anillin and p53 proteins in MCF-7 cells undergoing doxorubicin-induced senescence.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		fig4d_f_raw_data_western_blot_analysis_MCF_7.tab Tabular Data - Original format: MS Excel (XLSX) - 3.4 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 48 Observations - UNF:6:cRfTV2qWT5Be532Z24x9cA== Raw densitometry data corresponding to Fig. 4D and 4F. The dataset contains quantitative analysis of Western blot signals for anillin and p53 proteins in MCF-7 cells undergoing doxorubicin-induced senescence.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		fig4g_heatmap_scaled.tab Tabular Data - Original format: MS Excel (XLSX) - 226 B - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 13 Variables, 2 Observations - UNF:6:wR2dOeDa5/lCqxgCKdtYWw== Z-score normalized densitometric quantification of Western blot experiments measuring anillin and p53 protein levels in HCT116 and MCF-7 cells undergoing doxorubicin-induced senescence. This dataset contains the scaled data used to generate the heatmap shown in Fig. 4G.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		sup_fig1b_bgal_analysis_HCT116.tab Tabular Data - Original format: MS Excel (XLSX) - 1.4 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 22 Observations - UNF:6:CMVTfZ0UgMeNzX4d0stgGQ== Quantification of senescence-associated-β-galactosidase (SA-β-gal)-positive cells after induction of senescence with doxorubicin in HCT116 cells. This dataset contains the quantitative analysis used for Sup. Fig. 1B.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		sup_fig1c_brdu_analysis_HCT116.tab Tabular Data - Original format: MS Excel (XLSX) - 1.4 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 21 Observations - UNF:6:Si8HVF4kukn1+9khrCxdJA== Quantification of bromodeoxyuridine (BrdU)-positive cells after induction of senescence with doxorubicin in HCT116 cells. This dataset contains the quantitative analysis used for Sup. Fig. 1C.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		sup_fig1e_bgal_analysis_MCF_7.tab Tabular Data - Original format: MS Excel (XLSX) - 1.6 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 24 Observations - UNF:6:3U0CMjCHR76kAcwy6dXrSw== Quantification of senescence-associated-β-galactosidase (SA-β-gal)-positive cells after induction of senescence with doxorubicin in MCF-7 cells. This dataset contains the quantitative analysis used for Sup. Fig. 1E.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		sup_fig1f_brdu_analysis_MCF_7.tab Tabular Data - Original format: MS Excel (XLSX) - 1.5 KB - Apr 13, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 9 Variables, 22 Observations - UNF:6:l7E4kVlzSHU8DgvQzxYO2A== Quantification of bromodeoxyuridine (BrdU)-positive cells after induction of senescence with doxorubicin in MCF-7 cells. This dataset contains the quantitative analysis used for Sup. Fig. 1F.	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX

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