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A model of inflammatory bowel disease in pigs induced by 2,4-dinitrobenzenesulfonic acid (DNBS)

Version 1.0

Szkopek Dominika; Woliński Jarosław; Kopiasz Łukasz; Dziendzikowska Katarzyna; Zaworski Kamil; Sapierzyński Rafał; Gromadzka-Ostrowska Joanna, 2025, "A model of inflammatory bowel disease in pigs induced by 2,4-dinitrobenzenesulfonic acid (DNBS)", https://doi.org/10.18150/RGKXLF, RepOD, V1

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Description

Database from the study titled: "Efficacy of 2, 4-dinitrobenzenesulfonic acid (DNBS) in the maintenance of a model of inflammatory bowel disease in pigs". This study is a part of the research project titled: "Effect of beta glucan from oats in Crohn’s disease – a preclinical study".

The database contain:

  • the pigs' body weight measured weakly;
  • hematology results from two study periods: day 15 (the start of the in vivo experiment - before DNBS administration) and day 37 (the end of the in vivo experiment);
  • calprotectin concentration in feces from the two study periods: day 15 (the start of the in vivo experiment - before DNBS administration) and day 37 (the end of the in vivo experiment);
  • cytokines concentration (TNF-α and IL-1β), and alanine (ALT) and aspartate (AST) aminotransferases activity in plasma
  • histomorphometry results from the colon and small intestine (duodenum, proximal jejunum, middle jejunum, distal jejunum, and ileum).


Abbreviation for hematology results: white blood cells (WBC), percentage and absolute value of lymphocytes (LYM%, LYM#), percentage and absolute value of monocytes (MON%, MON#), percentage and absolute value of neutrophils (NEU%, NEU#), percentage and absolute value of eosinophils (EOS%, EOS#), percentage and absolute value of basophils (BASO%, BASO#), red blood cell (RBC), hemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width-coefficient of variation (RDW_CV), platelet count (PLT).

Subject
Medicine, Health and Life Sciences
Keyword

porcine colitis model, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, pigs, 2,4-dinitrobenzenesulfonic acid (DNBS)

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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1 to 10 of 10 Files
Body_weight.tab
Tabular Data - Original format: MS Excel (XLSX) - 1.5 KB - Aug 8, 2025 - 5 Downloads
License: CC BY - Creative Commons Attribution 4.0
11 Variables, 26 Observations - UNF:6:MiOpWNmEB1FrbAvwzC8ieg==
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Hematology.tab
Tabular Data - Original format: MS Excel (XLSX) - 7.8 KB - Aug 8, 2025 - 3 Downloads
License: CC BY - Creative Commons Attribution 4.0
40 Variables, 24 Observations - UNF:6:n2Oz+A28nkNaF25mwQopuQ==
Preview
Cytokines_and_aminotransferases.tab
Tabular Data - Original format: MS Excel (XLSX) - 2.8 KB - Aug 8, 2025 - 5 Downloads
License: CC BY - Creative Commons Attribution 4.0
10 Variables, 18 Observations - UNF:6:3wSvtPOpzCxjJSVGutyBKQ==
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Fecal_calprotectin.tab
Tabular Data - Original format: MS Excel (XLSX) - 1.5 KB - Aug 8, 2025 - 3 Downloads
License: CC BY - Creative Commons Attribution 4.0
10 Variables, 44 Observations - UNF:6:IwlWpEt1kd+IilUTGkbbvQ==
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Histomorphometry_colon.tab
Tabular Data - Original format: MS Excel (XLSX) - 21.9 KB - Aug 8, 2025 - 3 Downloads
License: CC BY - Creative Commons Attribution 4.0
17 Variables, 481 Observations - UNF:6:ofdmJkXe8tgHMe8KpC5Zrg==
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Histomorphometry_duodenum.tab
Tabular Data - Original format: MS Excel (XLSX) - 22.4 KB - Aug 8, 2025 - 2 Downloads
License: CC BY - Creative Commons Attribution 4.0
5 Variables, 356 Observations - UNF:6:NMGI8bGFfrcvtOhZm9HNRA==
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Histomorphometry_proximal_jejunum.tab
Tabular Data - Original format: MS Excel (XLSX) - 22.4 KB - Aug 8, 2025 - 4 Downloads
License: CC BY - Creative Commons Attribution 4.0
5 Variables, 357 Observations - UNF:6:/uQjt7Liz3nqs44Nl22PJw==
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Histomorphometry_middle_jejunum.tab
Tabular Data - Original format: MS Excel (XLSX) - 22.2 KB - Aug 8, 2025 - 2 Downloads
License: CC BY - Creative Commons Attribution 4.0
5 Variables, 364 Observations - UNF:6:z1De5MxH6XbErFjRXTeRNA==
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Histomorphometry_distal_jejunum.tab
Tabular Data - Original format: MS Excel (XLSX) - 22.2 KB - Aug 8, 2025 - 3 Downloads
License: CC BY - Creative Commons Attribution 4.0
5 Variables, 360 Observations - UNF:6:jH5uxNYrR+pcPetL3h1Skw==
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Histomorphometry_ileum.tab
Tabular Data - Original format: MS Excel (XLSX) - 22.1 KB - Aug 8, 2025 - 3 Downloads
License: CC BY - Creative Commons Attribution 4.0
5 Variables, 358 Observations - UNF:6:m0u3gQL0JgEuBXIKTAjt0A==
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