If you don't see your institution, add your dataset to the main dataverse named "RepOD".
Select the collection to which you want to add the new dataset:
You need to Sign In/Sign Up to add a dataset.
Share this dataset on your favorite social media networks.
Basta-Kaim, Agnieszka, 2026, "Hydrogen sulfide (H2S)-donating formyl peptide receptor 2 (FPR2) agonists: design, synthesis, and biological evaluation in primary mouse microglia culture", https://doi.org/10.18150/Q8LITR, RepOD, V1
Learn about Data Citation Standards.
Chronic neuroinflammation and oxidative stress play an important role in the onset and progression of neurodegenerative disorders, including Alzheimer’s disease, which can ultimately lead to neuronal damage and loss. This study aimed to evaluate the anti-inflammatory and pro-resolving potential of novel hybrid FPR2 agonists with hydrogen sulfide (H₂S)-releasing properties in an in vitro model of neuroinflammation.
The dataset comprises experimental data obtained from primary murine microglial cultures under basal conditions and following lipopolysaccharide (LPS) stimulation. The collection includes processed results from biochemical assays assessing inflammatory response and cell viability, including cytokine levels (ELISA), nitric oxide production (Griess assay), and cytotoxicity (LDH assay).
The dataset enables analysis of the effects of tested compounds on microglial activation and inflammatory signaling. Both compounds (7b and 8b) were able to counterbalance LPS-induced cytotoxicity and the release of pro-inflammatory (IL-18, IL-6) and anti-inflammatory (IL-10) cytokines induced by LPS stimulation.
neuroinflammation, anti-inflammation, hybrid compounds, neuroprotection
Brunetti L, Francavilla F, Niso M, Frydrych JK, Trojan E, Schepetkin IA, Kirpotina LN, Grygier B, Łukowicz K, Quinn MT, Basta-Kaim A, Lacivita E, Leopoldo M. Hydrogen Sulfide (H2S)-Donating Formyl Peptide Receptor 2 (FPR2) Agonists: Design, Synthesis, and Biological Evaluation in Primary Mouse Microglia Culture. Antioxidants (Basel). 2025 Jul 4;14(7):827. doi: 10.3390/antiox14070827. PMID: 40722931; PMCID: PMC12291851. https://doi.org/10.3390/antiox14070827 doi: doi: 10.3390/antiox14070827
CC BY - Creative Commons Attribution 4.0
Please select a file or files to be deleted.
The file(s) will be deleted after you click on the Delete button.
Files will not be removed from previously published versions of the dataset.
Please select a file or files to be edited.
For selected file(s) set a license to
Please select a file or files to be downloaded.
Please select a file or files for access request.
Please select restricted file(s) to be unrestricted.
You need to Log In/Sign Up to request access to this file.
Please confirm and/or complete the information needed below in order to continue.
Asterisks indicate required fields
Access to file(s) subject to additional consent under following conditions:
The restricted file(s) selected may not be downloaded because you have not been granted access.
Click Continue to download the files you have access to download.
Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.
Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.
Use a Anonymized Private URL to allow those without an account in the repository to access your dataset. For more information about the Private URL feature, please refer to the User Guide.
Private URL has not been created.
"WARNING. This dataset has at least one published version. Those who have access to the Anonymized Private URL for this dataset may be able to use its accessible metadata to look up the full, not anonymized version of this dataset.
Are you sure you want to disable the Private URL? If you have shared the Private URL with others they will no longer be able to use it to access your dataset.
Use a Private URL to allow those without an account in the repository to access your dataset. For more information about the Private URL feature, please refer to the User Guide.
You will not be able to make changes to this dataset while it is in review.
This dataset cannot be published until RepOD is published. Would you like to publish both right now?
Once you publish this dataset it must remain published.
Are you sure you want to republish this dataset?
Select if this is a minor or major version update.
This dataset cannot be published until RepOD is published by its administrator.
This dataset cannot be published until RepOD and are published.
Are you sure you want to deaccession? The selected version(s) will no longer be viewable by the public.
Are you sure you want to lift the embargo?
Once you lift the embargo, you will not be able to set it again.
RepOD repository support
Please fill this out to prove you are not a robot.
