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PRR polymorphisms in patients hospitalized for COVID-19

Version 1.0

Paradowska, Edyta, 2026, "PRR polymorphisms in patients hospitalized for COVID-19", https://doi.org/10.18150/NA2YBO, RepOD, V1

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Description

SARS-CoV-2 infection causes an innate immune response that is activated through pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs). Endosomal TLR7/8 detects viral ssRNA, while TLR3 also recognizes dsRNA formed during viral replication. Both RIG-I and MDA5 recognize SARS-CoV-2 RNA in the cytoplasm of infected cells. PRR pathways recruit essential downstream adapter proteins to induce type I interferons (IFNs) and inflammatory cytokines. 

PRR polymorphisms were genotyped in 261 individuals, including 166 patients hospitalized for COVID-19, and evaluated their associations with clinical parameters and serum cytokine profiles. Single-nucleotide polymorphisms (SNPs) of TLR3 (rs3775290 and rs3775291), TLR7 (rs179008, rs3853839, and rs5741880), TLR8 (rs3764879 and rs3764880), IFIH1 rs1990760, and DDX58 rs73479410 were genotyped using qPCR allelic discrimination, while TLR3 rs3775296 was analyzed by PCR-RFLP. Cytokine concentrations were quantified in 57 COVID-19 patients using MILLIPLEX Magnetic Bead Panels and Luminex xMAP technology. 

(2026-03-24)
Subject
Medicine, Health and Life Sciences
Keyword

SARS-CoV-2, COVID-19, cytokine and protein level, PRR polymorphism, TLR polymorphism, RLR polymorphism

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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PRR_SNP_genotyping_in_COVID19_patients.ods
Unknown - 10.6 KB - Apr 2, 2026 - 2 Downloads
MD5: 5f697357a5cbd12cb0572bee0d47991e
License: CC BY - Creative Commons Attribution 4.0
Genotyping of TLR3 (rs3775290 C>T; F459F and rs3775291 C>T; L412F), TLR7 (rs179008 A>T; Q11L, rs3853839 C>G, and rs5741880 G>T), TLR8 (rs3764879 C>G and rs3764880 A>G), IFIH1 (rs1990760 C>T; T946A), and DDX58 (rs73479410 G>A) was performed using TaqMan allelic discrimination assays. TLR3 rs3775296 C>A was analyzed using the PCR-RFLP method. Group: 1 - case, 0 - control; "NA" - not assigned.
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concentrations_of_cytokines_and_other_proteins_PRR_polymorphisms.ods
Unknown - 16.7 KB - Apr 2, 2026 - 1 Download
MD5: d9bd36a0786d782bf92b37584ce86b26
License: CC BY - Creative Commons Attribution 4.0
Serum samples were analyzed using the MILLIPLEX Human Cytokine/Chemokine/Growth Factor Panel A, including IFN-β, IFN-γ, IL-1RA, IL-4, IL-6, IL-8/CXCL8, IL-10, IL-18, IL-28A/IFN-λ2, IP-10/CXCL10, MCP-1, MCP-3, TNF-α, TNF-β, M-CSF, and MIP-1β. "NA" - not assigned.
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