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Kaczor, Agnieszka, 2025, "Mechanism of pharmacological activity of hydrogenated D2AAK1 derivatives", https://doi.org/10.18150/M96KIH, RepOD, V1
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This study reports 14 novel D2AAK1 derivatives with enhanced properties as neuroprotective agents. These derivatives were tested for their inhibition effects on AChE and MAO-B, as well as their effect on cell viability under oxidative stress. D2AAK1 derivatives showed strong cytoprotective effects, increasing cell viability by up to 300%. These effects are linked to MAPK p38 and Nrf2 pathway interactions, known to promote antioxidant and anti-apoptotic responses. In vivo studies indicated a beneficial effect of the tested derivative on the memory processes in the novel object recognition test. These findings identify D2AAK1 derivatives as potential agents for the treatment of memory deficits.
The following data are collected here:
The main finding of the study is discovery of D2AAK1 analogs more potent than a parent compound.
neurodegenerative diseases, neuroprotection, in vitro studies, behaviora studies
CC0 Creative Commons Zero 1.0
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