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GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex

Version 1.0

Urban-Ciećko, Joanna, 2025, "GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex", https://doi.org/10.18150/IZMSYE, RepOD, V1

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Description

Data set used for study published in the following paper:

Bogaj K, Kaplon R, Urban-Ciecko J. GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex. Front Cell Neurosci. 2023 Oct 12;17:1270219. doi: 10.3389/fncel.2023.1270219. PMID: 37900589; PMCID: PMC10602639.

 Raw data contains electrophysiological records in *.abf format (Clampfit, free online).

Abbreviations:            

VIP, vip - vasoactive intestinal polypeptide-expressing interneuron     

SST, sst - somatostatin-expressing interneuron

Pyr, pyr - pyramidal neuron

m - male

f - female

INs - interneurons

PTX - picrotoxin

THIP - 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol

GABAAR - receptor for gamma-aminobutyric acid type A

SD noise - Standard Deviation of the baseline noise

For more details see the related paper and/or contact the corresponding author. All the abbreviations are explained in the related paper.

(2025-04-04)
Subject
Medicine, Health and Life Sciences
Keyword

GABA, interneurons, GABAa receptors, somatostatin, SST, SOM, barrel cortex, neocortex, in vitro patch-clamp, electrophysiology, vasoactive intestinal polypeptide, tonic inhibition

Related Publication

Bogaj K, Kaplon R, Urban-Ciecko J. GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex. Front Cell Neurosci. 2023 Oct 12;17:1270219. doi: 10.3389/fncel.2023.1270219. PMID: 37900589; PMCID: PMC10602639. https://doi.org/10.3389/fncel.2023.1270219 doi: 10.3389/fncel.2023.1270219

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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1 to 6 of 6 Files
Readme.docx
MS Word (docx) - 24.4 KB - Apr 10, 2025 - 1 Download
MD5: 5c88f7f67c05c5e65c9dca72da8778fa
License: CC BY - Creative Commons Attribution 4.0
This file contains explanation for file names of raw data that were used for the study published in: Bogaj K, Kaplon R, Urban-Ciecko J. GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex. Front Cell Neurosci. 2023 Oct 12;17:1270219. doi: 10.3389/fncel.2023.1270219. PMID: 37900589; PMCID: PMC10602639. Raw data contains electrophysiological records in *.abf format (Clampfit)
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Figures_1_2_supplementary_figure_2.zip
ZIP Archive - 537.3 MB - Apr 10, 2025 - 1 Download
MD5: d6791d4366deea1ef3501fd076a6c5f6
License: CC BY - Creative Commons Attribution 4.0
The folder contains raw electrophysiological data for figures 1, 2 and supplementary figure 2. The comparison of tonic current density and SD noise in VIP-, SST-INs and Pyr neurons in ctrl and PTX.
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Figure_3_supplementary_figure_3.zip
ZIP Archive - 667.6 MB - Apr 10, 2025 - 0 Downloads
MD5: bed377cd9e5da7a6891416c601984ac3
License: CC BY - Creative Commons Attribution 4.0
The folder contains raw data for figures 3 and supplementary figure 3. The comparison of tonic current density and SD noise in VIP- and SST-INs in ctrl and THIP.
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Figure_4.zip
ZIP Archive - 356.2 MB - Apr 10, 2025 - 0 Downloads
MD5: 1ae0b0dae43b84a5db51a23bf0f9cb03
License: CC BY - Creative Commons Attribution 4.0
Raw data for figure 4. Spontaneous excitatory postsynaptic currents (sEPSCs) in VIP-, SST-INs and Pyr neurons (for the analysis of the amplitude and frequency).
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Figure_5_supplementary_figure_1A.zip
ZIP Archive - 139.4 MB - Apr 10, 2025 - 0 Downloads
MD5: 7742f3f78c8b23dbe70f6fa0e44c8622
License: CC BY - Creative Commons Attribution 4.0
Raw data for figures 5 and supplementary figure 1A: Intrinsic excitability and firing pattern of VIP-INs in control condition and after the application of PTX.
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Figure_6_supplementary_figure_1B.zip
ZIP Archive - 9.6 MB - Apr 10, 2025 - 1 Download
MD5: a7669801825613cf3f08187fe4e7a978
License: CC BY - Creative Commons Attribution 4.0
Raw data for figures 6 and supplementary figure 1B. Intrinsic excitability and firing patterns of SST-INs in control condition and after the application of PTX
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