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Development of an LC-MS method for the determination of simvastatin and its hydroxy acid form in muscle tissue

Version 1.0

Paszkowska, Ewa, 2024, "Development of an LC-MS method for the determination of simvastatin and its hydroxy acid form in muscle tissue", https://doi.org/10.18150/ICL1BG, RepOD, V1

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Description

The data describes parameters that were optimized during an LC-MS method validation. The method includes four compounds: simvastatin (SIM), simvastatin hydroxy acid (SIMA), lovastatin (LOV), and lovastatin hydroxy acid (LOVA). LOV and LOVA were used as internal standards, but are presented in the enclosed data.

MS scan spectra (both polarization positive/negative) and fragmentation spectra obtained with different collision energies were placed in the compressed folder Spectra.zip.

Solvents_for_homogenization_and_extraction.xls: presents signal intensity obtained for four compounds using different homogenization and extraction agents (mean value from three repetitions and RSD).

Proportion_for_homogenization_and_extraction.xls: presents signal intensities, average value, standard deviation, and RSD obtained for four compounds during optimization of proportion solvent to tissue at homogenization and extraction process.

Moreover, data describing chromatographic parameters optimization are included in the following files:

Comparison_mobile_phase.xls: presents peak intensities obtained for four compounds with different mobile phase A compositions.

Gradients.zip: show chromatograms obtained with different chromatographic elution (isocratic or gradient) with additional data describing the chromatographic parameters and gradient composition.

Files describing calibration curve:

Calibration_curves.zip: shows calibration curves plots in three repetitions with the curve equation and R2 value.

Calibration_curve.xls: presents data used to build calibration curves presented in zip file.

Subject
Medicine, Health and Life Sciences
Keyword

LC-MS, method validation, statin, muscle tissue

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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1 to 7 of 7 Files
Spectra.zip
ZIP Archive - 2.0 MB - Jun 21, 2024 - 1 Download
MD5: 73d903f6a889b20a6c1ebb0906fa1439
License: CC BY - Creative Commons Attribution 4.0
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Solvents_for_homogenization_and_extraction.tab
Tabular Data - Original format: MS Excel (XLSX) - 642 B - Jun 21, 2024 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
9 Variables, 8 Observations - UNF:6:qU7uGrLi1sbW9WeFItNoIA==
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Proportion_for_homogenization_and_extraction.tab
Tabular Data - Original format: MS Excel (XLSX) - 1.5 KB - Jun 21, 2024 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
8 Variables, 12 Observations - UNF:6:HO4/3O+DP3Is0SPauSJPhg==
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Comparison_mobile_phase.tab
Tabular Data - Original format: MS Excel (XLSX) - 635 B - Jun 21, 2024 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
6 Variables, 12 Observations - UNF:6:By6bAUN8UbxqdQ639bPqVw==
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Gradients.zip
ZIP Archive - 165.9 KB - Jun 21, 2024 - 0 Downloads
MD5: 2d157b1942e9358e301e6c7bf7341fb4
License: CC BY - Creative Commons Attribution 4.0
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Calibration_curves.zip
ZIP Archive - 259.7 KB - Jun 21, 2024 - 0 Downloads
MD5: 0ba8db7636ff73ae62aeb8abb2838f5b
License: CC BY - Creative Commons Attribution 4.0
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Calibration_curves.tab
Tabular Data - Original format: MS Excel (XLSX) - 1.3 KB - Jun 21, 2024 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
9 Variables, 15 Observations - UNF:6:DoToYA1QD0l8mtSqS2V4gQ==
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