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Activity of CD37-ADCs in rituximab-resistant and CD20-deficient Raji lymphoma models

Version 1.0

Poręba, Marcin, 2026, "Activity of CD37-ADCs in rituximab-resistant and CD20-deficient Raji lymphoma models", https://doi.org/10.18150/EGCHDT, RepOD, V1

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Description

These data evaluate CD37 targeting in Raji lymphoma models with rituximab resistance or CD20 loss. CD37-ADCs show cytotoxic activity in rituximab-resistant Raji cells and retain activity in CD20 knockout cells, although the magnitude depends on the ADC format, concentration, incubation time and cell line context. In parallel, anti-CD37-AF488 uptake experiments show strong time-dependent antibody uptake in Raji WT and rituximab-resistant cells, reduced uptake in sgNTC cells, and markedly lower uptake in CD20 knockout cells, supporting a link between CD20 status, CD37 uptake and ADC response.

Subject
Medicine, Health and Life Sciences
Keyword

CD37, CD20, B-cell lymphoma, Raji cells, rituximab resistance, CD20 knockout, antibody–drug conjugate, CD37-ADC, ADC cytotoxicity, antibody uptake, Alexa Fluor 488, target internalization, immunotherapy resistance, antigen modulation, lymphoma therapy

Related Publication

Malgorzata Bobrowicz, Aleksandra Kusowska, Marta Krawczyk, Andriy Zhylko, Christopher Forcados, Aleksander Slusarczyk, Joanna Barankiewicz, Joanna Domagala, Matylda Kubacz, Michal Šmída, Lenka Dostalova, Katsiaryna Marhelava, Klaudyna Fidyt, Monika Pepek, Iwona Baranowska, Anna Szumera-Cieckiewicz, Else Marit Inderberg, Sébastien Wälchli, Monika Granica, Agnieszka Graczyk-Jarzynka, Martyna Majchrzak, Marcin Poreba, Carina Lynn Gehlert, Matthias Peipp, Malgorzata Firczuk, Monika Prochorec-Sobieszek, Magdalena Winiarska, 2024, CD20 expression regulates CD37 levels in B-cell lymphoma – implications for immunotherapies, OncoImmunology, 13, 1, 1-12 https://doi.org/10.1080/2162402X.2024.2362454 doi: 10.1080/2162402X.2024.2362454

CC BY - Creative Commons Attribution 4.0 CC BY - Creative Commons Attribution 4.0

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CD37ADC_cytotoxicity.pdf
Adobe PDF - 2.2 MB - Jul 23, 2026 - 0 Downloads
MD5: 768c9fc279d5f1e44d870946ac43b1c2
License: CC BY - Creative Commons Attribution 4.0
Cytotoxicity of antiCD37 ADCs
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CD37Alexa488_MM.pdf
Adobe PDF - 6.4 MB - Jul 23, 2026 - 0 Downloads
MD5: 0e5247eba4e12870ab4024ba6f5e231d
License: CC BY - Creative Commons Attribution 4.0
Cellular uptake of anti-CD37-fluorophore conjugates
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Total_Integeated_Intensity_standard_deviation_raw_data.tab
Tabular Data - Original format: MS Excel (XLSX) - 6.8 KB - Jul 23, 2026 - 0 Downloads
License: CC BY - Creative Commons Attribution 4.0
17 Variables, 47 Observations - UNF:6:FX2PKpGxFgs4YogC+RVQEg==
Raw data on the Anti-CD37-flurophore cellular uptake
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AUC_Wwa.pzfx
Unknown - 28.0 KB - Jul 23, 2026 - 0 Downloads
MD5: 993c2c2fae1486c6e6e7fe1df151f50c
License: CC BY - Creative Commons Attribution 4.0
Processed data on the anti-CD37-fluorophoe cellular uptake
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