The present work aimed to assess whether the different concentrations of the coelomic fluid of D. veneta may affect human platelets and blood coagulation.
List of used abbreviations:
PBS - Phosphate Buffered Saline
ASA – aspirin
Ekstrakt stęż. 25 – extract with a concentration of 25 µg/mL
Ekstrakt stęż. 50– extract with a concentration of 50 µg/mL
Ekstrakt stęż. 100 – extract with a concentration of 100 µg/mL
ASPI – ASPItest, aggregation in response to 0.5 mM arachidonic acid (aggregation in response to 0.5 mM arachidonic acid)
ADP – ADPtest, platelet aggregation in response to 6.5 µM adenosine-5′-diphosphate
TRAP – TRAPtest, aggregation in response to 32 µM thrombin receptor activating peptide 6 (aggregation in response to 32 µM thrombin receptor activating peptide 6)
PT – prothrombin time
U, UA – unit used in ASPItest, ADPtest, TRAPtest
INR – International Normalized Ratio, used to monitor the effectiveness of anticoagulants
PR - protrombin ratio (%)
Equipment used for ASPI, ADP, TRAP tests: Multiplate® Platelet Function Testing 5.0 Analyzer (Roche, Rotkreuz, Switzerland
(2023)
