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Torlińska-Walkowiak, Natalia, 2026, "Genetic variant analysis in children with growth hormone deficiency and dental developmental defects", https://doi.org/10.18150/A26BKA, RepOD, V1
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Growth hormone plays an important role in the processes of dental cell differentiation and tissue formation, and studies indicate an increased prevalence of hypodontia in children with growth hormone deficiency. Therefore, investigating variants in the candidate genes PAX9, MSX1, and WNT10A in children with growth hormone deficiency may provide valuable insights into developmental mechanisms. Importantly, genes involved in tooth development may also participate in pituitary gland development. Identification of sequence variants in these genes may therefore contribute to a better understanding of the mechanisms underlying both hypodontia and growth hormone deficiency, as well as to more precise diagnosis and treatment of patients.
The coding regions of the PAX9, MSX1, and WNT10A genes were analyzed using Sanger sequencing in two groups, each comprising 50 children: patients with short stature and children with normal height constituting the control group.
The results presented include an analysis of allele frequencies for 10 genetic variants located within the analyzed genes.
tooth agenesis, gene variants, growth hormone deficiency
2029-10-01
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