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Poręba, Marcin, 2026, "Biochemical and biological characterization of cathepsin selective ADCs in HER2 positive breast cancer", https://doi.org/10.18150/7KZ5PW, RepOD, V1
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The data and metadata entered into the system relate to the results presented in the publication entitled “Engineering unnatural amino acids in peptide linkers enables cathepsin-selective antibody-drug conjugates for HER2-positive breast cancer” by Gorzeń et al., published in Journal of Controlled Release in 2025. The dataset concerns the design, synthesis, characterization, and biological evaluation of cathepsin-selective peptide linkers, prodrugs, and trastuzumab-based antibody–drug conjugates. It also includes data related to enzymatic profiling, protease-dependent payload release, ADC cytotoxicity in HER2-positive breast cancer models, plasma stability, and single-cell mass cytometry analysis of patient-derived breast cancer samples. The metadata describe the experimental context, assay types, biological models, analytical methods, and publication-level information associated with these results.
antibody-drug conjugates, unnatural amino acids, protease-activated prodrugs, Cathepsin L, Cathepsin B, breast cancer, mass cytometry, CyTOF, HER-2, trastuzumab, monomethyl auristatin E
Oliwia Gorzeń, Maria Łęcka, Natalia Ćwilichowska-Puślecka, Martyna Majchrzak, Natalia Horbach, Jerzy Wiśniewski, Piotr Jakimowicz, Paweł Szpot, Marcin Zawadzki, Bartosz Dołęga-Kozierowski, Piotr Kasprzak, Boris Turk, Marcin Drąg, Katarzyna M. Groborz, Rafał Matkowski, Marcin Poręba, 2025, Engineering unnatural amino acids in peptide linkers enables cathepsin-selective antibody-drug conjugates for HER2-positive breast cancer, Journal of Controlled Release, 387, 1-19 https://doi.org/10.1016/j.jconrel.2025.114269 doi: 10.1016/j.jconrel.2025.114269
CC BY - Creative Commons Attribution 4.0
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