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Mazurkiewicz, Wojciech; Linfield, Steven; Wójtowicz, Tomasz; Koprowska, Joanna; Witkowska Nery, Emilia, 2026, "Improved antifouling efficiency at decreased switching potential using graphene oxide-silicate matrix co-deposit at carbon fiber microelectrodes", https://doi.org/10.18150/6CDFWJ, RepOD, V1
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Carbon fiber microelectrodes (CFMEs) have been widely used as implantable tools for in vivo, real-time neurotransmitter monitoring via fast scan cyclic voltammetry (FSCV). While the commonly applied switching potential of +1.3 V yields desirable surface regeneration, resultant carbon oxidative etching alters electrode area and contributes to background drift. Within this article’s framework, we proposed a modification layer for carbon fiber microdisk electrodes to provide fouling resistance at a reduced switching potential of +1.0 V. Namely, we applied a cathodic potential to co-deposit reduced graphene oxide and a tetramethoxysilane-derived silicate matrix (rGO-SM-CFME). This layer was subsequently oxidized to yield graphene oxide-silicate matrix modification (GO-SM-CFME). rGO-SM-CFMEs exhibit a manifold increase in area and, thus, sensitivity toward neurotransmitter detection. While they are suitable for experiments at low scan rates, the cell time constant on the order of milliseconds excludes them from FSCV research. On the other hand, we showed that GO-SM-CFMEs are less susceptible to fouling by dopamine oxidation byproducts in a model solution, maintaining ±10% accuracy in the dopamine oxidation current over 3 days. A subsequent study in mouse brain tissue with electrodes implanted in the striatum also confirmed that GO-SM-CFMEs exhibit greater resistance to fouling, with a smaller decrease in the dopamine oxidation current than CFMEs. While results are promising, further research should be conducted with cylindrical microelectrodes, as the faradaic current associated with the area of microdisk electrodes is comparable to noise levels in physiological conditions, which impedes their ability to detect electrically stimulated responses.
carbon fiber microelectrode, FSCV, dopamine, neurotransmitter, antifouling, graphene oxide, silicate matrix
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