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Nencki Institute of Experimental Biology

(Instytut Biologii Doświadczalnej im. Marcelego Nenckiego)

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Research data for: Unconventional myosin VI is involved in regulation of muscle energy metabolism

Version 1.0

Lehka, Lilya, 2026, "Research data for: Unconventional myosin VI is involved in regulation of muscle energy metabolism", https://doi.org/10.18150/5MXFJH, RepOD, V1

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Description

The files contain the research data described in the manuscript entitled: Unconventional myosin VI is involved in regulation of muscle energy metabolism.

The dataset comprises quantitative measurements of MVI mRNA expression and protein levels, as well as real-time analysis of Prkaa2 expression and assessment of muscle fiber type composition in MVI-KO mice compared with WT controls. It also includes colocalization analyses of MVI and TOM20 in myoblasts, myotubes, and isolated soleus muscle fibers.

Additionally, the dataset contains measurements of oxygen consumption rates in C2C12 cells (Scrambled and MVI-KD) and in primary myoblasts isolated from MVI-KO mice, mitochondrial membrane potential in primary myoblasts from MVI-KO and WT mice, and densitometric analyses of key proteins involved in skeletal muscle metabolism.

Further data include ATP production ratios, triglyceride concentrations, epididymal fat pad weight–to–body weight ratios, and overall body weight measurements.

This research was conducted as part of a project funded by the National Science Centre (Poland) under the Sonata 18 program [grant number 2022/47/D/NZ3/02737].

(2026-02-27)

Subject

Medicine, Health and Life Sciences

Keyword

energy metabolism, mitochondria, muscle fiber types, skeletal muscle, unconventional myosin VI

Related Publication

Wojton D, Dymkowska D, Matysniak D, Topolewska M, Redowicz MJ, Lehka L. Unconventional myosin VI is involved in regulation of muscle energy metabolism. Am J Physiol Cell Physiol. 2025 Oct 1;329(4):C1004-C1021. Epub 2025 Aug 18. PMID: 40824825. https://doi.org/10.1152/ajpcell.00300.2025 https://doi.org/10.1152/ajpcell.00300.2025 doi: 10.1152/ajpcell.00300.2025

License

CC BY - Creative Commons Attribution 4.0

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			Original Format Archival Format (.tab)
		Fig1_B.tab Tabular Data - Original format: MS Excel (XLSX) - 615 B - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 11 Variables, 11 Observations - UNF:6:pauKC0CUby2Hz+HH183pAQ== Myo6 expression in hindlimb muscles	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig1_D.tab Tabular Data - Original format: MS Excel (XLSX) - 416 B - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 12 Variables, 5 Observations - UNF:6:YFTQqHuOYZ+tBaJCM3BAWQ== Densitometry analysis of MVI protein level	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig2_A.tab Tabular Data - Original format: MS Excel (XLSX) - 1.4 KB - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 43 Variables, 13 Observations - UNF:6:8qLn2W92cl9td4hLRqgyCw== Fiber type composition in MVI-KO muscles	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig2_C.tab Tabular Data - Original format: MS Excel (XLSX) - 919 B - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 35 Variables, 15 Observations - UNF:6:cGCSacGFa/NLM9kQI6zL1g== Quantification of NADH-TR staining of MVI-KO soleus muscle	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig3_A.tab Tabular Data - Original format: MS Excel (XLSX) - 8.0 KB - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 6 Variables, 237 Observations - UNF:6:d4nnKi7VRm4RqikGw/328Q== MVI and TOM20 colocalization in myoblasts	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig3_B.tab Tabular Data - Original format: MS Excel (XLSX) - 6.9 KB - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 3 Variables, 222 Observations - UNF:6:PfQyCvgKPlql9HyuYsRikQ== MVI and TOM20 colocalization in myocytes	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig3_C.tab Tabular Data - Original format: MS Excel (XLSX) - 3.3 KB - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 3 Variables, 110 Observations - UNF:6:Msw8F+gTZ5dGkaqPN6g8Jw== MVI and TOM20 colocalization in myotubes	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig3_D.tab Tabular Data - Original format: MS Excel (XLSX) - 17.0 KB - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 5 Variables, 606 Observations - UNF:6:2mjkYD+qQtGMIBiKwPghIw== MVI and TOM20 colocalization in myofibers isolated from 3-month-old soleus muscle	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig3_E.tab Tabular Data - Original format: MS Excel (XLSX) - 14.2 KB - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 5 Variables, 598 Observations - UNF:6:NhjNuK2BzXdnJFkvt/ocfg== MVI and TOM20 colocalization in myofibers isolated from 12-month-old soleus muscle	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX
		Fig4_A.tab Tabular Data - Original format: MS Excel (XLSX) - 894 B - Mar 18, 2026 - 0 Downloads License: CC BY - Creative Commons Attribution 4.0 5 Variables, 14 Observations - UNF:6:lxnLY0awRU2wFdKXs3FRww== Measurement of oxygen consumption rate in C2C12 murine myoblast cells	Preview Original File Format (MS Excel (XLSX)) Tab-Delimited RData Format Variable Metadata Data File Citation RIS EndNote XML BibTeX

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