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Kassassir, Hassan, 2026, "Effect of platelet-derived microparticles on the colorectal cancer-vascular endothelium crosstalk - data from in vitro and in vivo study.", https://doi.org/10.18150/41XFAP, RepOD, V1
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The aim of the research was to verify the effect on platelet-derived microparticles (PMP) on the interaction between colorectal cancer cells (CRC) and vascular endothelium.
Raw data have been deposited including: (i) Effect of PMP on the adhesion of fluorescently labelled CRC cells to monolayers of HMEC-1 cells in the presence of incorporation inhibitor Dynasore. CRC cells alone, HMEC-1 cells alone or both CRC cells and HMEC-1 cells were preincubated with PMP and with or without the addition of the dynamine inhibitor, Dynasore. The data are presented as the number of adhered, fluorescently labeled CRC cells; (ii) The effect of PMP and conditioned medium of PMP-stimulated CRC cells on the integrity of the HMEC-1 cell monolayer. The data are presented as the area covered with fluorescently labelled HMEC-1 cells; (iii) Permeability of the PMP-stimulated HMEC-1 monolayer for the passage of Dextran-FITC. The data are presented as fluorescence values measured at 488 nm; (iv) The mRNA expression of intercellular junction proteins (PECAM-1, ZO-1 and VE-cadherin) in HMEC-1 cells treated with PMP or conditioned medium of PMP-stimulated CRC cells. The data are presented as the fold change in relative to that of unstimulated cells; (v) Expression of PECAM-1 and ZO-1 on the surface of CRC cells incubated with PMP or with conditioned medium of PMP-stimulated CRC cells. The data are presented as the MFI values; (vi) Normalised densitometric values of PECAM-1 and ZO-1 expression in PMP-stimulated HMEC-1 cells, in relative to those of unstimulated cells; (vii) Migration of fluorescently labelled CRC cells through monolayer of PMP-stimulated HMEC-1 cells; (viii) The data are presented as number of migrated fluorescently labeled CRC cells; (ix) Concentrations of total MMP-2 and human MMP-9 in the plasma obtained from mice treated with selected lines of CRC cells and intravenously injected with PMP. The data are presented as ng/ml of MMP-2/MMP-9 in plasma; (x) Expression of CD62P and αIIbβ3 on resting and thrombin-stimulated platelets obtained from a CRC mouse model intravenously injected with PMP. The data are presented as a percentage of CD62P- or αIIbβ3-positive platelets; (xi) Quantified data of the adhesion of fluorescently labelled HT29, SW480 and SW620 cells to monolayers of HMEC-1 cells. CRC cells alone, HMEC-1 cells alone or both CRC cells and HMEC-1 cells were preincubated with PMP. The data are presented as the number of adhered, fluorescently labeled CRC cells; (xii) The effect of Dynasore on the incorporation of PMP into CRC cells; (xiii) The effect of PMPs on the level of plasma inflammatory markers in CRC in vivo model. The data are presented as pg/ml of MCP-1, TNF-α, IFN-γ, IL-10 and IL-6 in plasma from CRC mouse model intravenously injected with PMPs; (xiv) Size distribution of PMPs isolated from thrombin-stimulated platelets, measured by using NTA (Nanoparticle Tracking Analysis).
Data are presented in ODS files. Each ODS file refers to separate figure presented in the publication linked to these data.
Blood platelets, Colorectal cancer, Platelet microparticles
Papiewska-Pająk I, Kassassir H, Moczkowska W, Braun M, Rybicka A, Boncela J, Kowalska MA. Platelet-derived microparticles increase the interaction of colorectal cancer cells with the endothelium to promote metastatic events. J Transl Med. 2025 Jul 25;23(1):843. https://doi.org/10.1186/s12967-025-06858-9 doi: 10.1186/s12967-025-06858-9
CC BY - Creative Commons Attribution 4.0
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