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Zimecki, Michał, 2025, "Age-Dependent Effects of Yolkin on Contact Sensitivity and Immune Phenotypes in Juvenile Mice", https://doi.org/10.18150/3R9OFF, RepOD, V1
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Yolkin, an egg yolk immunoregulatory protein, stimulates the humoral but inhibits the cellular immune response in adult mice. Assuming that yolkin may promote maturation of the immunocompetent cells, we evaluated the effects of yolkin on the cellular and humoral immune response (oxazolone and ovalbumin, respectively), in juvenile 28- and 37-day-old mice, Yolkin was administered in drinking water before immunization. The results showed that yolkin had a stimulatory effect on the cellular immune response in the mice treated with yolkin from the 37th day of life but not from the 28th day of life. No regulatory effects of yolkin on antibody production were found in these mice. Phenotypic studies revealed significant changes in the content of B cells and T cell subpopulations including CD4+CD25+Foxp3 regulatory T cells. The results revealed a short age frame in the adolescent mice when the changes in the content of immunocompetent cells (the increases in helper T cell phenotype and the decrease in regulatory T cells) could explain the stimulatory effect of yolkin on the cellular immune response.
The detailed description of the dataset is presented in readme.txt file.
The experimental methodology is included in the linked publication.
juvenile mice, yolkin, contact sensitivity, ovalbumin, regulatory T cells
https://www.mdpi.com/1420-3049/29/14/3254 doi: 10.3390/molecules29143254
CC BY - Creative Commons Attribution 4.0
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